380471-69-2Relevant academic research and scientific papers
Synthesis of New Oxindoles and Determination of Their Antibacterial Properties
Romo, Pablo E.,Insuasty, Braulio,Abonia, Rodrigo,Crespo, María Del Pilar,Quiroga, Jairo
, (2020)
A versatile method for the synthesis of new oxindoles was developed by the reaction between substituted isatins and 5-aminopyrazoles. The reaction was carried out at room temperature in ethanol using p-toluenesulfonic acid as the catalyst. The products we
Efficient Domino Strategy for the Synthesis of Substituted Bipyrazole Derivatives
Zhang, Xi,Long, Kai,He, Jiayi,Fu, Jialian,Zhang, Furen,Li, Chunmei
, p. 729 - 735 (2018)
An efficient domino strategy for the synthesis of bipyrazole derivatives has been established successfully using Y(OTf)3 as catalyst. This new reaction allows direct formation of highly functionalized bipyrazole derivatives with a wide diversity in substituents in a one-pot manner. The present synthesis shows attractive characteristics, such as the use of water as reaction media, simple one-pot operation, highly efficient catalyst, and mild reaction conditions.
New four-component reactions in water: A convergent approach to the metal-free synthesis of spiro[indoline/acenaphthylene-3,4′-pyrazolo[3,4-b] pyridine derivatives
Balamurugan, Kamaraj,Perumal, Subbu,Menéndez, J. Carlos
supporting information; experimental part, p. 3201 - 3208 (2011/05/30)
New four-component domino reactions are described that allow the one-pot synthesis of spiro[indoline/acenaphthylene-3,4′-pyrazolo[3,4-b]pyridine derivatives from the reaction of phenylhydrazine, 3-aminocrotononitrile, isatin/acenaphthylene-1,2-dione, and
Efficient one-pot synthesis of spiro[indoline-3,4′-pyrazolo[3,4-e][1, 4]thiazepine]dione via three-component reaction
Chen, Hui,Shi, Daqing
experimental part, p. 5686 - 5692 (2011/08/09)
An efficient one-pot synthesis of spiro[indoline-3,4′-pyrazolo[3,4-e] [1,4]thiazepine] dione derivatives via three-component reaction of 5-amino-3-methylpyrazole, isatin, and thioacid is described. This new protocol produces novel heptacyclic spirooxindole derivatives in good yields in comparison to conventional pentacyclic compounds. This method proceeds through a 3-(5-aminopyrazol-3-yl)-3-hydroxy-2-oxindoline intermediate (Baylis-Hillman type adduct), unlike 3-indolylimine (the intermediate like Shiff-Bases) as in conventional methods. The structure of one representative compound has been confirmed by X-ray diffraction analysis.
Efficient one-pot synthesis of novel spirooxindole derivatives via three-component reaction in aqueous medium
Chen, Hui,Shi, Daqing
scheme or table, p. 571 - 576 (2010/08/20)
A novel and efficient one-pot synthesis of spiro[indoline-3,4′- pyrazolo[3,4-b]quinoline]dione, spiro[furo[3,4-e]pyrazolo[3,4-b]pyridine-4, 3′-indoline]dione, and spiro[indeno[2,1-e]pyrazolo[3,4-b]pyridine-4, 3′-indoline]dione derivatives via three-component reaction of isatin, 5-amino-3-methylpyrazole, and 1,3-dicarbonyl compounds in aqueous medium is described. The advantages of this method include high efficiency, mild reaction conditions, convenient operation, and environmentally benign conditions.
