38052-24-3

Usage

Class

Pyrazinones

Use

Building block in organic chemistry and pharmaceutical research

Potential applications

Synthesis of various pharmaceuticals, key ingredient in the development of new chemical compounds

Studied for

Biological and pharmacological properties

Importance

Subject of research in medicine and drug development

Upstream product

• 57355-08-5 3,5,6-trimethyl-1,2-dihydropyrazin-2-one 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 97382-53-1 N-Methyl-N-(2-oxo-propionyl)-acetamide 

Relevant academic research and scientific papers

SYNTHESIS OF STABLE 3,6-EPIDIOXYPYRAZIN-2-ONES AND α-OXO IMIDES BY PHOTOOXYGENATION OF PYRAZIN-2-ONES WITH SINGLET OXYGEN

Irradiation of the pyrazin-2-ones (1) in methanol under oxygen gave the 3,6-epidioxypyrazin-2-ones (2), the N-alkyl-N-acyl-α-oxo-amides (3), and the unusual products, N-alkyl-α-acyloxy-α-methoxy amides (4).The mechanism for the formation of these photoproducts is discussed.Furthermore, thermal or photochemical treatment of the 3,6-epidioxypyrazinones (2), which could be readily obtained by the reaction of (1) and singlet oxygen, gave the N-alkyl-N-acyl-α-oxo amides (3) and this reaction would provide a useful synthetic method for the α-oxo imides (3).