380607-15-8

Basic information

• Product Name: 6-BROMO-2H-CHROMENE-3-CARBOXYLIC ACID
• Synonyms: BUTTPARK 52\08-04;6-BROMO-2H-CHROMENE-3-CARBOXYLIC ACID
• CAS NO: 380607-15-8
• Molecular Formula: C10H7BrO3
• Molecular Weight: 255.06
• Mol File: 380607-15-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 380.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.734±0.06 g/cm3(Predicted)
• PKA: 3.54±0.20(Predicted)
• CAS DataBase Reference: 6-BROMO-2H-CHROMENE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2H-CHROMENE-3-CARBOXYLIC ACID(380607-15-8)
• EPA Substance Registry System: 6-BROMO-2H-CHROMENE-3-CARBOXYLIC ACID(380607-15-8)

Safety Data

• Hazardous Substances Data: 380607-15-8(Hazardous Substances Data)

Usage

General Description

6-Bromo-2H-chromene-3-carboxylic acid is a chemical compound with the molecular formula C10H7BrO3. It is a derivative of chromene, a class of organic compounds with a benzopyran backbone. 6-BROMO-2H-CHROMENE-3-CARBOXYLIC ACID contains a bromo group and a carboxylic acid functional group, which makes it useful in medicinal chemistry and organic synthesis. It has been studied for its potential pharmaceutical properties, including its anti-inflammatory and antibacterial effects. Additionally, it can be used as a building block for the synthesis of other biologically active compounds.

Upstream product

• 548756-58-7 tert-butyl 3-(5-bromo-2-hydroxyphenyl)-3-hydroxy-2-methylenenpropanoate 
• 57543-68-7 6‐bromo‐2H‐chromene‐3‐carbonitrile 
• 1761-61-1 5-bromosalicyclaldehyde 

Downstream Products

• 939758-95-9 3-amino-chroman-6-carboxylic acid methyl ester 

Relevant articles and documents

Strong base- or acid-mediated chemoselectivity shifts in the synthesis of 2H-chromene or coumarin derivatives from common Baylis-Hillman adducts

Abstract Reaction of tert-butyl 3-(2-hydroxyphenyl)-2-methylenepropanoate esters with aqueous KOH provides convenient and chemoselective one-pot access to 2H-chromene-3-carboxylic acids, the overall transformation involving tandem conjugate addition, hydrolysis and elimination steps. The methodology complements the chemoselective, acid-catalysed route to 3-substituted coumarins from the same substrates by switching the regioselectivity of cyclisation.

NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, wherein R1 to R3 and X have the significances given herein. The present invention is also directed to proc