38061-23-3

Basic information

• Product Name: Phenylalanine, b-oxo-, methyl ester, hydrochloride
• CAS NO: 38061-23-3
• Molecular Formula: C10H11NO3.ClH
• Molecular Weight: 229.663
• Mol File: 38061-23-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Phenylalanine, b-oxo-, methyl ester, hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Phenylalanine, b-oxo-, methyl ester, hydrochloride(38061-23-3)
• EPA Substance Registry System: Phenylalanine, b-oxo-, methyl ester, hydrochloride(38061-23-3)

Safety Data

• Hazardous Substances Data: 38061-23-3(Hazardous Substances Data)

Upstream product

• 81167-39-7 methyl N-(diphenylmethylene)glycinate 
• 98-88-4 benzoyl chloride 
• 147744-97-6 methyl 2-((tert-butoxycarbonyl)amino)-3-oxo-3-phenylpropanoate 
• 93-97-0 benzoic acid anhydride 
• 38061-18-6 methyl 5-phenyl-4-oxazolecarboxylate 

Downstream Products

• 116129-92-1 methyl (2S,3S)-2-amino-3-hydroxy-3-phenylpropanoate 
• 50707-28-3 methyl (2R,3R)-2-amino-3-hydroxy-3-phenylpropionate 
• 17193-41-8 (2RS,3RS)-2-amino-3-hydroxy-3-phenyl-propionic acid methyl ester; hydrochloride 
• 17193-36-1 (2S*,3R*)-2-tert-butoxycarbonylamino-3-hydroxy-3-phenyl-propionic acid methyl ester 
• 1104494-04-3 methyl (2R,3R)-2-(benzoylamino)-3-hydroxy-3-phenylpropanoate 
• 38114-29-3 erythro-methyl 2-amino-3-hydroxy-3-phenylpropanoate 
• 6857-34-7 2-mercapto-4⁽⁵⁾-phenylimidazole 
• 64220-19-5 2-mercapto-4-phenylimidazole-5-carboxylic acid 
• 19185-84-3 methyl (2R,3S)-2-benzoylamino-3-hydroxy-3-phenylpropionate 

Relevant articles and documents

OXAZOLE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

Enantioselective synthesis of anti-β-hydroxy-α-amido esters by asymmetric transfer hydrogenation in emulsions

Herein, we present two methods for an asymmetric transfer hydrogenation through the dynamic kinetic resolution of α-amido-β-ketoesters. These procedures yield the corresponding anti-β-hydroxy-α-amido esters in good yields and with good diastereo- and enantioselectivities. First, the scope of the reduction of α-amido-β-ketoesters by using triethylammonium formate azeotrope is examined. Then, an emulsion technology with sodium formate is explored, which allows for broader substrate scope, faster reaction times, and lower catalyst loading. Furthermore, these reactions are operationally simple and can be set up in air.

PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE BETA-HYDROXY- ALPHA-AMINOCARBOXYLIC ACID DERIVATIVES

There is provided a process for efficiently producing an anti form of an optically active β-hydroxy-α-aminocarboxylic acid derivative that is useful as an intermediate for pharmaceuticals and agrochemicals. The process for producing optically active β-hydroxy-α-aminocarboxylic acid derivative of formula (2) or (3) wherein R1 is substituted or unsubstituted C1-20 alkyl group, or substituted or unsubstituted C4-12 aromatic group, R2 is substituted or unsubstituted C1-20 alkyl group, or substituted or unsubstituted C4-12 aromatic group, characterized by comprising subjecting an α-aminoacyl acetic acid ester compound of formula (1) wherein R1 and R2 have the same meaning as the above, to hydrogenation by catalytic asymmmetric hydrogenation in the presence of an acid.