380636-40-8

Basic information

• Product Name: 6-Carboxyl-4-phenyl-3,4-dihydrocouMarin Cinchonidine
• Synonyms: 6-Carboxyl-4-phenyl-3,4-dihydrocouMarin Cinchonidine;6-Carboxyl-4-phenyl-3,4-dihydrocouMarin Cinchonidine Salt
• CAS NO: 380636-40-8
• Molecular Formula: C₁₆H₁₂O₄*C₁₉H₂₂N₂O
• Molecular Weight: 562.67
• Mol File: 380636-40-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Carboxyl-4-phenyl-3,4-dihydrocouMarin Cinchonidine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Carboxyl-4-phenyl-3,4-dihydrocouMarin Cinchonidine(380636-40-8)
• EPA Substance Registry System: 6-Carboxyl-4-phenyl-3,4-dihydrocouMarin Cinchonidine(380636-40-8)

Safety Data

• Hazardous Substances Data: 380636-40-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Carboxyl-4-phenyl-3,4-dihydrocoumarin Cinchonidine is used as an intermediate in the synthesis of (R)-5-Hydroxymethyl Tolterodine Formate (H949480), a metabolite of Tolterodine (T535800). Tolterodine is a muscarinic receptor antagonist that is utilized in the treatment of urinary incontinence. Its role in the synthesis process highlights its importance in the development of medications for this specific medical condition.

Upstream product

• 140-10-3 (E)-3-phenylacrylic acid 
• 356782-33-7 (R,S)-4-phenyl-2-chromanone-6-carboxylic acid 
• 118-10-5 cinchonidine 

Downstream Products

• 380636-39-5 (R)-4-phenyl-2-chromanone-6-carboxylic acid 
• 960373-30-2 (R)-6-hydroxymethyl-4-phenylchroman-2-(RS)-ol 
• 960373-32-4 (R)-4-phenyl-2-chromanone-6-carbonyl chloride 
• 380636-42-0 methyl (R)-2-oxo-4-phenylchromane-6-carboxylate 

Relevant articles and documents

NEW CHIRAL INTERMEDIATE, PROCESS FOR PRODUCING THE SAME AND ITS USE IN THE MANUFACTURE OF TOLTERODINE, FESOTERODINE, OR THE ACTIVE METABOLITE THEREOF

The compound of formula (I): is provided. It may be produced by subjecting a compound of formula (IV) to a reduction reaction wherein R represents hydrogen, straight or branched C1-C6 alkyl. This compound is a valuable intermediate which may be used in the synthesis of fesoterodine, tolterodine, its active metabolite, and related compounds.