960373-32-4

Upstream product

• 99-76-3 methyl 4-hydroxylbenzoate 
• 140-10-3 (E)-3-phenylacrylic acid 
• 380636-40-8 (R)-4-phenyl-2-chromanone-6-carboxylic acid cinchonidine salt 
• 356782-33-7 (R,S)-4-phenyl-2-chromanone-6-carboxylic acid 
• 380636-39-5 (R)-4-phenyl-2-chromanone-6-carboxylic acid 

Downstream Products

• 380636-42-0 methyl (R)-2-oxo-4-phenylchromane-6-carboxylate 
• 960373-30-2 (R)-6-hydroxymethyl-4-phenylchroman-2-(RS)-ol 

Relevant academic research and scientific papers

NEW CHIRAL INTERMEDIATE, PROCESS FOR PRODUCING THE SAME AND ITS USE IN THE MANUFACTURE OF TOLTERODINE, FESOTERODINE, OR THE ACTIVE METABOLITE THEREOF

The compound of formula (I): is provided. It may be produced by subjecting a compound of formula (IV) to a reduction reaction wherein R represents hydrogen, straight or branched C1-C6 alkyl. This compound is a valuable intermediate which may be used in the synthesis of fesoterodine, tolterodine, its active metabolite, and related compounds.

Shortened synthesis of 3,3-diarylpropylamine derivatives

The invention relates to a method for producing derivatives of 3,3-diarylpropylamines of general formula (I) and sterically highly pure, stable intermediate products, and to their use for producing pharmaceutical compositions.