380654-37-5Relevant academic research and scientific papers
Sequential change in one-pot, three-component protocol: A stepping stone in heterocyclic synthesis
Raja, Ranganathan,Murugan, Dinesh,Sivasubramaniyan, Archana,George, Jaabil,Perumal, Sakthivel,Alagusundaram, Ponnuswamy,Jayakumar, Mohan Raj,Saminathan, Murugavel
, p. 942 - 948 (2016)
Two different heterocycles, thiazole-2-imines and imidazole-2-thiones, have been conveniently synthesized by just altering the sequential order (1+2+3 or 1+3+2) when combining the same components [aryl amine (1), aryl isothiocyanate (2), and phenacyl bromide (3)] in one-pot, three-component protocols. The third possible sequential order of combination (2+3+1) chemoselectively affords thiazole-2-imine. The finding is a stepping stone in the synthetic applicability of sequential one-pot, three-component protocols.
