38073-45-9

Basic information

• Product Name: (Z)-2-(2'-methoxybenzylidene)-1,2-dihydroindol-3-one
• Synonyms: (Z)-2-(2'-methoxybenzylidene)-1,2-dihydroindol-3-one
• CAS NO: 38073-45-9
• Molecular Weight: 251.285
• Mol File: 38073-45-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-2-(2'-methoxybenzylidene)-1,2-dihydroindol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(2'-methoxybenzylidene)-1,2-dihydroindol-3-one(38073-45-9)
• EPA Substance Registry System: (Z)-2-(2'-methoxybenzylidene)-1,2-dihydroindol-3-one(38073-45-9)

Safety Data

• Hazardous Substances Data: 38073-45-9(Hazardous Substances Data)

Upstream product

• 123134-55-4 C₁₆H₁₅NO₂ 
• 135-02-4 ortho-anisaldehyde 
• 551-93-9 2-aminoacetophenone 

Relevant articles and documents

In quest of small-molecules as potent non-competitive inhibitors against influenza

A series of scaffolds namely aurones, 3-indolinones, 4-quinolones and cinnamic acid-piperazine hybrids, was designed, synthesized and investigated in vitro against influenza A/H1N1pdm09 virus. Designed molecules adopted different binding mode i.e., in 430-cavity of neuraminidase, unlike sialic acid and oseltamivir in molecular docking studies. All molecules reduced the viral titer and exhibited non-cytotoxicity along with cryo-protective property towards MDCK cells. Molecules (Z)-2-(3′-Chloro-benzylidene)-1,2-dihydro-indol-3-one (2f), (Z)-2-(4′-Chloro-benzylidene)-1,2-dihydro-indol-3-one (2g) and 2-(2′-Methoxy-phenyl)-1H-quinolin-4-one (3a) were the most interesting molecules identified in this research, endowed with robust potencies showing low-nanomolar EC50 values of 4.0 nM, 6.7 nM and 4.9 nM, respectively, compared to reference competitive and non-competitive inhibitors: oseltamivir (EC50 = 12.7 nM) and quercetin (EC50 = 0.56 μM), respectively. Besides, 2f, 2g and 3a exhibited good neuraminidase inhibitory activity in sub-micromolar range (IC50 = 0.52 μM, 3.5 μM, 1.3 μM respectively). Moreover, these molecules were determined as non-competitive inhibitors similar to reference non-competitive inhibitor quercetin unlike reference competitive inhibitor oseltamivir in kinetics studies.