380895-63-6

Basic information

• Product Name: trans-1-(4-methoxy-phenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester
• Synonyms: trans-1-(4-methoxy-phenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester
• CAS NO: 380895-63-6
• Molecular Weight: 336.39
• Mol File: 380895-63-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: trans-1-(4-methoxy-phenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: trans-1-(4-methoxy-phenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester(380895-63-6)
• EPA Substance Registry System: trans-1-(4-methoxy-phenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester(380895-63-6)

Safety Data

• Hazardous Substances Data: 380895-63-6(Hazardous Substances Data)

Upstream product

• 7524-52-9 (S)-tryptophan methyl ester hydrochloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 73-22-3 L-Tryptophan 
• 4299-70-1 L-tryptophan methyl ester 
• 109086-77-3 2-(4'-methoxyphenyl)perhydro-1,3-oxazine 

Downstream Products

• 1461750-00-4 (5aS,12R,14aS)-12-(4-methoxyphenyl)-1,2,3,5a,6,14a-hexahydropyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14(11H,12H)-dione 

Relevant articles and documents

4-methoxyphenyl substituted tetrahydro-beta-carboline piperazine dione derivative and uses thereof

The invention relates to a 4-methoxyphenyl substituted tetrahydro-beta-carboline piperazine dione derivative and uses thereof, and specifically discloses a compound represented by a formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, wherein each group is defined in the specification. According to the present invention, the compound has dual inhibitory activity onacetylcholinesterase and phosphodiesterase 5, and has good blood-brain barrier permeability, such that the compound can be used for preparing drugs for treatment and/or prevention of Alzheimer's diseases. The formula I is defined in the specification.

Enantioselective synthesis and antimicrobial activities of tetrahydro-β-carboline diketopiperazines

A series of single isomers tetrahydro-β-carboline diketopiperazines were stereoselectively synthesized starting from l-tryptophan methyl ester hydrochloride and six aldehydes through a four-step reaction including Pictet-Spengler reaction, crystallization-induced asymmetric transformations (CIAT), Schotten-Baumann reaction, and intramolecular ester amidation. The chemical structures were characterized by nuclear magnetic resonance (NMR) and elemental analysis, among which two compounds were determined by x-ray single crystal diffraction. Moreover, antimicrobial activities of all the compounds were also tested. Chirality 25:656-662, 2013. 2013 Wiley Periodicals, Inc.

Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-β-carbolines as a new class of antimalarial agents

A series of hybrid molecules 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-β-carbolines have been synthesized and screened for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum. Compounds 26, 32, and 34 have shown MIC in the range of 0.05-0.11 μM and are in vitro several folds more active than chloroquine.