380899-53-6Relevant academic research and scientific papers
Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders
Di Fabio, Romano,Pellacani, Annalisa,Faedo, Stefania,Roth, Adelheid,Piccoli, Laura,Gerrard, Philip,Porter, Rod A.,Johnson, Christopher N.,Thewlis, Kevin,Donati, Daniele,Stasi, Luigi,Spada, Simone,Stemp, Geoffrey,Nash, David,Branch, Clive,Kindon, Leanda,Massagrande, Mario,Poffe, Alessandro,Braggio, Simone,Chiarparin, Elisabetta,Marchioro, Carla,Ratti, Emiliangelo,Corsi, Mauro
scheme or table, p. 5562 - 5567 (2011/10/12)
The hypothalamic peptides orexin-A and orexin-B are potent agonists of two G-protein coupled receptors, namely the OX1 and the OX2 receptor. These receptors are widely distributed, though differentially, in the rat brain. In particul
NOVEL COMPOUNDS
-
Page/Page column 32; 43, (2009/02/11)
Disclosed are imidazo[1,2-a]pyridin-2-ylmethyl substituted piperidine derivatives of formula (I) and their use as pharmaceuticals.
POLYMORPH FORMS OF (S)-2-((4-BENZOFURANYL)CARBONYLAMINOMETHYL)-1-((4-(2-METHYL-5-(4-FLUOROPHENYL)THIAZOLYL)CARBONYL)PIPERIDINE
-
Page/Page column 19, (2009/04/25)
New crystalline forms of (S)-2-((4-benzofuranyl)carbonylamino methyl)-1-((4-(2-methyl-5-(4-fluorophenyl))thiazolyl)carbonyl)piperidine, methods for their preparation and use in medicine as orexin receptor antagonist.
