433283-22-8

Usage

Uses

Used in Pharmaceutical Industry:
RAC-5-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid is used as a potential therapeutic agent for various applications due to its pharmacological properties. Its antibacterial activity makes it a candidate for the development of new antibiotics to combat resistant bacterial strains. Its antifungal properties could lead to the creation of novel antifungal drugs to treat fungal infections. Furthermore, its anticancer potential suggests that it may be used in the development of anticancer drugs, targeting various types of cancer cells and potentially enhancing the efficacy of existing chemotherapy treatments.
Used in Antibacterial Applications:
RAC-5-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid is used as an antibacterial agent for its ability to inhibit the growth of bacteria, making it a potential candidate for the development of new antibiotics to address the growing issue of antibiotic resistance.
Used in Antifungal Applications:
RAC-5-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid is used as an antifungal agent for its potential to treat fungal infections by inhibiting the growth and proliferation of fungi, offering a new approach to combat fungal diseases.
Used in Anticancer Applications:
RAC-5-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid is used as an anticancer agent for its potential to target and inhibit the growth of cancer cells, making it a promising candidate for the development of novel anticancer drugs. Its ability to enhance the efficacy of existing chemotherapy treatments and overcome drug resistance in cancer cells further highlights its potential in cancer therapy.

InChI:InChI=1/C11H8FNO2S/c1-6-13-9(11(14)15)10(16-6)7-2-4-8(12)5-3-7/h2-5H,1H3,(H,14,15)

Upstream product

• 1007873-79-1 methyl 5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylate 
• 160727-95-7 methyl 3-chloro-3-(4-fluorophenyl)-2-oxopropanoate 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 690244-83-8 1-(3-((5-bromo-pyrimidin-2-ylamino)-methyl)-3,4-dihydro-1H-isoquinolin-2-yl)-1-(5-(4-fluoro-phenyl)-2-methyl-thiazol-4-yl)-methanone 
• 1097265-07-0 2-[((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}-2-piperidinyl)methyl]-7-(trifluoromethyl)imidazo[1,2-a]pyridine 
• 380899-53-6 5-(4-fluoro-phenyl)-2-methyl-thazole-4-carbonyl chloride 
• 1260527-46-5 (+/-)-(5-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone 
• 1260527-49-8 (+/-)-methyl 5-chloro-2-((6-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-azaspiro[2.5]octan-5-yl)methylamino)benzoate 

Relevant academic research and scientific papers

SUBSTITUTED 2-AZABICYCLO[3.1.1]HEPTANE AND 2-AZABICYCLO[3.2.1]OCTANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

There is provided a compound of formula (I), wherein L1 to L3, R1 to R4, X, A and B have meanings given in the description, and pharmaceutically acceptable salts, solvates and prodrugs thereof, which compounds are useful as antagonists of the orexin-1 and orexin-2 receptors or as selective antagonists of the orexin-1 receptor, and thus, in particular, in the treatment or prevention of inter alia substance dependence, addiction, anxiety disorders, panic disorders, binge eating, compulsive disorders, impulse control disorders, cognitive impairment and Alzheimer's disease.

2-AZA-BICYCLO[3.3.0]OCTANE DERIVATIVES

The invention relates to 2-aza-bicyclo[3.3.0]octane derivatives of Formula (I) wherein A, B, and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

THIAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to thiazolidine derivatives of the formula (I) wherein A, B, and R1 are as described in the description, to salts, especially pharmaceutically acceptable salts, of such compounds and to their use as medicaments, especially

1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to novel azetidine compounds of formula (I), wherein R1, R2, and X are as described in the description and their use as orexin receptor antagonists.

3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to 3-aza-bicyclo[3.1.0]hexane derivatives of formula (I) wherein A, B, n, X, and R1 are as described in the description, and salts thereof, and their use as orexin receptor antagonists.

THIAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to thiazolidine derivatives of the formula (I) wherein A, B, and R1 are as described in the description, to salts, especially pharmaceutically acceptable salts, of such compounds and to their use as medicaments, especially

3-HETEROARYL (AMINO OR AMIDO)-1-(BIPHENYL OR PHENYLTHIAZOLYL) CARBONYLPIPERIDINE DERIVATIVES AS OREXIN RECEPTOR INHIBITORS

The invention relates to piperidine compounds of formula (I) wherein X-R1 represents —N(H)-pyrimidinyl, wherein said pyrimidinyl is unsubstituted or mono-substituted wherein the substituent is selected from (C1-4)alkyl or halogen, or

OXAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to oxazolidine derivatives of the formula (I) wherein A, B, and R1 are as described in the description, to salts, especially pharmaceutically acceptable salts, of such compounds and to their use as medicaments, especially

THIAZOLIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to novel thiazolidine derivatives of the formula (I) wherein A and R1 are as described in the description and their use as medicaments, especially as orexin receptor antagonists.