381-84-0 Usage
Uses
Used in Pharmaceutical Industry:
2-Trifluoromethyl acrylonitrile is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique reactivity and the presence of the trifluoromethyl group contribute to the development of new drugs with improved pharmacological properties, such as enhanced bioavailability and potency.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Trifluoromethyl acrylonitrile serves as a crucial building block for the creation of novel agrochemicals. Its incorporation into these compounds can lead to the development of more effective pesticides and herbicides, potentially increasing crop yields and protecting against a broader range of pests.
Used in Advanced Materials Industry:
2-Trifluoromethyl acrylonitrile is utilized in the production of advanced materials, such as specialty polymers and high-performance plastics. The trifluoromethyl group imparts specific properties to these materials, including increased thermal stability, chemical resistance, and improved mechanical strength.
Used as an Intermediate in Organic Synthesis:
Beyond its direct applications, 2-Trifluoromethyl acrylonitrile is also employed as an intermediate in organic synthesis. Its reactivity allows for the formation of a variety of complex organic molecules, which can be further used in different industries, including the synthesis of fine chemicals and specialty chemicals.
Safety Precautions:
Given the flammability and potential health hazards associated with 2-Trifluoromethyl acrylonitrile, it is imperative to implement proper safety measures during its handling and storage. This includes adherence to strict safety protocols to minimize the risk of accidents and ensure the well-being of those involved in its use.
Check Digit Verification of cas no
The CAS Registry Mumber 381-84-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,8 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 381-84:
(5*3)+(4*8)+(3*1)+(2*8)+(1*4)=70
70 % 10 = 0
So 381-84-0 is a valid CAS Registry Number.
InChI:InChI=1/C4H2F3N/c1-3(2-8)4(5,6)7/h1H2
381-84-0Relevant academic research and scientific papers
Delivering Structural Information on the Polar Face of Membrane-Active Peptides:19F-NMR Labels with a Cationic Side Chain
Michurin, Oleg M.,Afonin, Sergii,Berditsch, Marina,Daniliuc, Constantin G.,Ulrich, Anne S.,Komarov, Igor V.,Radchenko, Dmytro S.
supporting information, p. 14595 - 14599 (2016/11/23)
Conformationally constrained non-racemizing trifluoromethyl-substituted lysine isosteres [(E)- and (Z)-TCBLys] with charged side chains are presented as a new type of19F-NMR labels for peptide studies. Design of the labels, their synthesis, incorporation into peptides and experimental demonstration of their application for solid state NMR studies of membrane-active peptides are described. A series of fluorine-labeled analogues of the helical amphipathic antimicrobial peptide PGLa(Nle) was obtained, in which different lysine residues in the original peptide sequence were replaced, one at a time, by either (E)- or (Z)-TCBLys. Antimicrobial activities of the synthesized analogues were practically the same as those of the parent peptide. The structural and orientational parameters of the helical PGLa(Nle) peptide in model bilayers, as determined using the novel labels confirmed and refined the previously known structure. (E)- and (Z)-TCBLys, as a set of cationic19F-NMR labels, were shown to deliver structural information about the charged face of amphipathic peptides by solid state19F-NMR, previously inaccessible by this method.
