70158-59-7

Basic information

• Product Name: 2,5-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE
• Synonyms: 2,5-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE;2,5-Dichloro-alpha,alpha,alpha-trifluoro-3-picoline;2,5-Dichloro-3-(trifluoromethyl)
• CAS NO: 70158-59-7
• Molecular Formula: C₆H₂Cl₂F₃N
• Molecular Weight: 215.99
• Mol File: 70158-59-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 80-82/26mm°
• Boiling Point: 80-82/26mm°
• Flash Point: 71℃
• Appearance: /
• Density: 1.542
• Vapor Pressure: 0.666mmHg at 25°C
• Refractive Index: 1.47
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -4.07±0.10(Predicted)
• CAS DataBase Reference: 2,5-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE(70158-59-7)
• EPA Substance Registry System: 2,5-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE(70158-59-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 70158-59-7(Hazardous Substances Data)

Usage

General Description

2,5-dichloro-3-(trifluoromethyl)pyridine is a chemical compound with the molecular formula C7H3Cl2F3N. It is a pyridine derivative that contains two chlorine atoms and a trifluoromethyl group attached to the third carbon atom in the pyridine ring. 2,5-dichloro-3-(trifluoromethyl)pyridine is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in the production of other organic compounds. 2,5-dichloro-3-(trifluoromethyl)pyridine is a colorless to pale yellow liquid that is sparingly soluble in water and more soluble in organic solvents. It is important to handle this compound with caution as it may be harmful if swallowed, inhaled, or in contact with skin.

InChI:InChI=1/C6H2Cl2F3N/c7-3-1-4(6(9,10)11)5(8)12-2-3/h1-2H

Upstream product

• 80289-91-4 2,5,6-trichloro-3-tirfluoromethylpyridine 
• 59782-85-3 2,5-dichloronicotinic acid 
• 381-84-0 2-(trifluoromethyl)acrylonitrile 
• 75-87-6 chloral 

Downstream Products

• 651292-91-0 tert-butyl (1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)carbamate 
• 173304-15-9 2-(5-chloro-3-trifluoromethyl-2-pyridyloxymethyl)phenyl 5-methylisoxazol-3-yl ketone O-methyloxime 
• 129015-69-6 (5-chloro-3-(trifluoromethyl)pyridin-2-yl)hydrazine 

Relevant articles and documents

Preparation method of 2-chloro-3-trifluoromethylpyridine

The invention discloses a preparation method of 2-chlorine- 3-trifluoromethylpyridine. The method comprises the following steps: (1), sequentially adding 2, 3, 6-trichloro-5-trifluoromethylpyridine, an acid-binding agent and a catalyst into a lower aliphatic alcohol solvent, and starting a circulating water pump to replace hydrogen in vacuum, with the addition amount of the catalyst being 0.01-0.5% of the reaction system; (2), controlling the temperature of the reductive dechlorination reaction to be -10-65 DEG C, the reaction hydrogen pressure to be 0.1-2.0 MPa and the reaction time to be 4-24 hours; and (3), filtering, rectifying and purifying the obtained reaction liquid in sequence to finish separation of corresponding products and unreacted raw materials. The preparation method of the2-chlorine-3-trifluoromethylpyridine, provided by the invention is simple in process, easy to operate and beneficial to industrial production, the obtained product is high in purity, the purity is greater than 98%, a plurality of useful products are produced at one time, and on the basis of the selectivity of the useful products, the selectivity is 95%, the conversion rate of a single raw material is over 95%, and the production cost is low.

Process for the production of chloropyridines substituted by methyl, trichloromethyl or trifluoromethyl groups

Chloropyridines of the formula STR1 wherein either R is chlorine and R' is methyl or trifluoromethyl, or R is methyl, trichloromethyl or trifluoromethyl and R' is chlorine, or R and R' are methyl, can be obtained by a novel, simple process by the addition of trichloroacetaldehyde to methacrylonitrile or α-trifluoromethacrylonitrile, 2,2-dichloropropionaldehyde, pentachloropropionaldehyde or 2,2-dichloro-3,3,3-trifluoropropionaldehyde to acrylonitrile, or 2,2-dichloropropionaldehyde to methacrylonitrile, in the presence of a catalyst, in particular copper powder or copper(I) chloride, and cyclizing the open-chain intermediate obtained. The chloropyridines of the formula (I) are known per se and are suitable for the production of different compounds, in particular of insecticides and herbicides.