70158-59-7

Usage

Uses

Used in Pharmaceutical Industry:
2,5-dichloro-3-(trifluoromethyl)pyridine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2,5-dichloro-3-(trifluoromethyl)pyridine serves as an essential intermediate for the production of pesticides and other agrochemicals, contributing to the development of effective solutions for crop protection.
Used as a Building Block in Organic Synthesis:
2,5-dichloro-3-(trifluoromethyl)pyridine is utilized as a building block in the synthesis of other organic compounds, enabling the creation of a wide range of chemical products with diverse applications across various industries.

InChI:InChI=1/C6H2Cl2F3N/c7-3-1-4(6(9,10)11)5(8)12-2-3/h1-2H

Upstream product

• 381-84-0 2-(trifluoromethyl)acrylonitrile 
• 75-87-6 chloral 
• 59782-85-3 2,5-dichloronicotinic acid 
• 80289-91-4 2,5,6-trichloro-3-tirfluoromethylpyridine 

Downstream Products

• 651292-91-0 tert-butyl (1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)carbamate 
• 173304-15-9 2-(5-chloro-3-trifluoromethyl-2-pyridyloxymethyl)phenyl 5-methylisoxazol-3-yl ketone O-methyloxime 
• 129015-69-6 (5-chloro-3-(trifluoromethyl)pyridin-2-yl)hydrazine 

Relevant academic research and scientific papers

Preparation method of 2-chloro-3-trifluoromethylpyridine

The invention discloses a preparation method of 2-chlorine- 3-trifluoromethylpyridine. The method comprises the following steps: (1), sequentially adding 2, 3, 6-trichloro-5-trifluoromethylpyridine, an acid-binding agent and a catalyst into a lower aliphatic alcohol solvent, and starting a circulating water pump to replace hydrogen in vacuum, with the addition amount of the catalyst being 0.01-0.5% of the reaction system; (2), controlling the temperature of the reductive dechlorination reaction to be -10-65 DEG C, the reaction hydrogen pressure to be 0.1-2.0 MPa and the reaction time to be 4-24 hours; and (3), filtering, rectifying and purifying the obtained reaction liquid in sequence to finish separation of corresponding products and unreacted raw materials. The preparation method of the2-chlorine-3-trifluoromethylpyridine, provided by the invention is simple in process, easy to operate and beneficial to industrial production, the obtained product is high in purity, the purity is greater than 98%, a plurality of useful products are produced at one time, and on the basis of the selectivity of the useful products, the selectivity is 95%, the conversion rate of a single raw material is over 95%, and the production cost is low.

Deoxofluorination of (Hetero)aromatic Acids

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

Process for the production of chloropyridines substituted by methyl, trichloromethyl or trifluoromethyl groups

Chloropyridines of the formula STR1 wherein either R is chlorine and R' is methyl or trifluoromethyl, or R is methyl, trichloromethyl or trifluoromethyl and R' is chlorine, or R and R' are methyl, can be obtained by a novel, simple process by the addition of trichloroacetaldehyde to methacrylonitrile or α-trifluoromethacrylonitrile, 2,2-dichloropropionaldehyde, pentachloropropionaldehyde or 2,2-dichloro-3,3,3-trifluoropropionaldehyde to acrylonitrile, or 2,2-dichloropropionaldehyde to methacrylonitrile, in the presence of a catalyst, in particular copper powder or copper(I) chloride, and cyclizing the open-chain intermediate obtained. The chloropyridines of the formula (I) are known per se and are suitable for the production of different compounds, in particular of insecticides and herbicides.

Herbicidal pyridine compounds

Herbicidal 3- and/or 5-halogenomethyl-pyrid-2-yloxyphenoxy compounds and processes for making and using the same. Intermediates for making these compounds and their preparation are also disclosed. Thus, for example, 2-chloro-5-trichloromethylpyridine is prepared by a liquid phase chlorination of 3-methylpyridine under the influence of ultra violet light.