38101-97-2

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(4-nitrophenyl)-2-(quinolin-2-yl)ethanol is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of drugs that treat a wide range of diseases. Its unique structure allows it to interact with specific biological targets, enhancing its utility in drug design and discovery.
Used in Organic Compounds Production:
In the chemical industry, 1-(4-nitrophenyl)-2-(quinolin-2-yl)ethanol is utilized as a key component in the production of specialty chemicals. Its structural properties make it a versatile compound for creating a variety of organic compounds with different applications.
Used in Medicinal Chemistry Research:
Due to its potential biological activities, 1-(4-nitrophenyl)-2-(quinolin-2-yl)ethanol is also used as a subject of interest for further research and development within the field of medicinal chemistry. Its interactions with biological targets make it a promising candidate for exploring new therapeutic approaches and understanding complex biological processes.
Safety Note:
It is important to handle 1-(4-nitrophenyl)-2-(quinolin-2-yl)ethanol with care and to review its safety data thoroughly before use to ensure safe and effective application in various industries.

Upstream product

• 91-63-4 2-methylquinoline 
• 555-16-8 4-nitrobenzaldehdye 
• 619-73-8 4-nitrobenzyl chloride 

Downstream Products

• 38101-93-8 2-[(E)-2-(4-nitrophenyl)ethenyl]quinoline 
• 108165-95-3 4-[(E)-2-(2-quinolinyl)ethenyl]aniline 

Relevant academic research and scientific papers

Ru(II)–NNO pincer-type complexes catalysed E-olefination of alkyl-substituted quinolines/pyrazines utilizing primary alcohols

An efficient and selective E-olefination of alkyl-substituted quinolines and pyrazines through acceptorless dehydrogenative coupling of alcohols catalysed by Ru(II)–N^N^O pincer-type complexes encompassing carbonyl and triphenylarsines as co-ligands is de

α-Chymotrypsin–catalyzed direct C (Sp3)–H functionalization reactions for synthesis of azaarene derivatives in water

α-Chymotrypsin from the bovine pancreas has been shown for the first time to display catalytic nonnatural catalytic ability toward the C (sp3)–H functionalization reaction of 2-methylquinoline and aromatic aldehydes in water. α-Chymotrypsin exhibited favorable catalytic activity with good adaptability to different substrates. The activity of the enzyme could be improved by adjusting the solvent, temperature, molar ratio of substrates, and protein loading. The products were obtained in moderate to excellent yields (51%-93%) in 24 samples. This process afforded a potential biocatalytic approach as an alternative to chemical synthesis for azaarene derivatives.

Method for preparing 1-aryl-2-quinolyl ethanol compound by catalysis of acidic ionic liquid

The invention discloses a method for preparing a 1-aryl-2-quinolyl ethanol compound by catalysis of acidic ionic liquid and belongs to the technical field of chemical material preparation. The methodfor preparing the 1-aryl-2-quinolyl ethanol compound by

Magnetically separable CuFe2O4 nanoparticles as a recoverable catalyst for the addition reaction of C(sp3)-H bond of azaarenes to aldehydes

A green and efficient protocol for the copper ferrite (CuFe2O4) nanoparticle-catalyzed direct C(sp3)-H bond functionalization of 2-alkyl azaarenes has been developed. The magnetic catalyst can be recovered and recycled by a simple magnetic separation from the reaction solution and reused eight times without significant decrease in catalytic activity. This journal is

Acid ionic liquid promoted addition of C(sp3)-H bond to aldehyde

A novel protocol for acid ionic liquid promoted C(sp3)-H bond functionalization of alkyl azaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields, which provides an efficient approach for the synthesis of alkyl-substituted azaarene derivatives. It is worthwhile to note that acid ionic liquid used for this reaction can be recycled and reused six times without a significant decrease in activity.

Microwave assisted water mediated benzylic C-H functionalization of methyl aza-arenes and nucleophilic addition to aromatic aldehydes

A highly efficient method is described for the sp3 C-H bond functionalization of methyl aza-arenes in the presence of water under microwave irradiation and subsequent addition to aromatic aldehydes. This transformation represents an efficient way to synthesize 2-alkyl aza-arene derivatives from simple starting materials.

Bronsted acid promoted benzylic C-H bond functionalization of azaarenes: Nucleophilic addition to aldehydes

A practical Bronsted acid promoted benzylic C-H functionalization of 2-methylazaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields. A six-membered hydrogen-bonding transition state is proposed to be crucial for the reaction. Ready availability of the two starting materials, the use of acetic acid as the catalyst and the facile reaction conditions will guarantee this synthetic method attractive to the synthesis of bioactive pyridine and quinoline derivatives.

Biological evaluation of substituted quinolines

Several quinolines were synthesized and evaluated in vitro against several parasites (Trypanosoma brucei, T. cruzi, Leishmania infantum, L. amazonensis, Plasmodium falciparum). Then, they were evaluated in vitro (at 10μM), against HTLV-1 transformed cells