38115-24-1Relevant academic research and scientific papers
Superelectrophilic chemistry of amino-nitriles and related substrates
Raja, Erum K.,Klumpp, Douglas A.
experimental part, p. 4494 - 4497 (2011/07/08)
The superacid-promoted Houben/Hoesch reactions of amino-nitriles and related compounds have been studied. The nitriles form dicationic electrophiles and react with benzene in fair to good yields (12-95%). The intermediate iminium ions may also be reduced to the benzylic amines by NaBH4 or H 2.
KINETICS AND MECHANISM OF REACTION OF AMINES WITH β-BROMOPROPIOPHENONE
Popov, A. F.,Piskunova, Z.,Matvienko, V. N.
, p. 1299 - 1302 (2007/10/02)
The reaction of β-bromopropiophenone with different amines in acetonitrile at 25 deg C was studied.It was found that in the case of primary and secondary amines, the end products of the reaction are β-aminopropiophenones, which form via the intermediate phenyl vinyl ketone.In the case of tertiary amines, the reaction ends at the stage of the formation of phenyl vinyl ketone.The reactivity of the amines in the formation of phenyl vinyl ketone is preferentially determined by their basicity.
