381200-35-7

Basic information

• Product Name: 2-(4-CHLORO-BENZYL)-BENZOOXAZOL-5-YLAMINE
• Synonyms: 2-(4-CHLORO-BENZYL)-BENZOOXAZOL-5-YLAMINE;AKOS BB-8108;ASISCHEM B52453;ART-CHEM-BB B025161;TIMTEC-BB SBB009758;2-(4-CHLORO-BENZYL)-BENZOOXAZOLE-5-YLAMINE
• CAS NO: 381200-35-7
• Molecular Formula: C₁₄H₁₁ClN₂O
• Molecular Weight: 258.7
• Mol File: 381200-35-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-CHLORO-BENZYL)-BENZOOXAZOL-5-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLORO-BENZYL)-BENZOOXAZOL-5-YLAMINE(381200-35-7)
• EPA Substance Registry System: 2-(4-CHLORO-BENZYL)-BENZOOXAZOL-5-YLAMINE(381200-35-7)

Safety Data

• Hazardous Substances Data: 381200-35-7(Hazardous Substances Data)

Usage

Molecular Structure

2-(4-chloro-benzyl)-benzoxazol-5-ylamine consists of a benzooxazol ring with a 4-chloro-benzyl group attached to it.

Type of Compound

It is an organic compound.

Usage

It is commonly used as a building block in organic synthesis and as a reagent in chemical reactions.

Potential Applications

The compound has potential applications in pharmaceuticals, agrochemicals, and materials science.

Chemical Properties

Versatile chemical structure and properties.

Safety

It is important to handle this chemical carefully and follow proper safety protocols, as it may pose health and environmental risks if mishandled.

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 95-86-3 2,4-diaminophenol 
• 137-09-7 2,4-diaminophenol dihydrochloride 

Downstream Products

• 1610037-92-7 2-(4-chlorobenzyl)-5-(4-nitrophenylsulfonamido)benzoxazole 
• 1030530-17-6 C₂₃H₁₅ClN₂O₃ 

Relevant articles and documents

Synthesis, antimicrobial activity, density functional modelling and molecular docking with COVID-19 main protease studies of benzoxazole derivative: 2-(p-chloro-benzyl)-5-[3-(4-ethly-1-piperazynl) propionamido]-benzoxazole

This study contains synthesis, antimicrobial activity, density functional modelling and molecular docking studies of benzoxazole derivative: 2-(p-chloro-benzyl)-5-[3-(4-ethly-1-piperazynl) propionamido]-benzoxazole. The synthetic procedure of investigated

Synthesis of some piperazinobenzoxazole derivatives and their antimicrobial properties

A series of 2-(p-substitutedphenyl/benzyl)-5-[3-[4-[(p-chlorophenyl)/phenyl]piperazin-1-yl]propionamido]-benzoxazoles (3-22) have been synthesized towards discovering new antimicrobial compounds in order to fight against pathogens, which have become resistant to antibiotics and are the cause of increased mortality and morbidity throughout the world. Structures of new derivatives have been elucidated by spectral techniques. New and previously synthesized benzoxazoles have been evaluated for their antibacterial and antifungal activity against standard strains, and their drug-resistant isolates in comparison with reference drugs. This study is aimed to investigate the efficacy of the antimicrobial effect of different amido bridges on the same homologue structures of benzoxazole compounds. Compounds 3-22 exhibit broad antibacterial activity with MIC (Minimum Inhibitory Concentration) values of 128-256 μg/mL against Staphylococcus aureus and its isolate except for derivative 7 that has a MIC value of 32 μg/mL against S. aureus isolate and compounds 3 and 22 which have MIC value of 512 μg/mL against S. aureus. Also, the tested compounds 3-22 possess low antifungal activity with MIC values of 128 μg/mL against Candida albicans in comparison with antifungal reference drugs, fluconazole and amphotericin B.

Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles

The synthesis and antimicrobial activity of a new series of 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazole derivatives 3-12 were described. The in vitro antimicrobial activity of the compounds was determined against some Gram-positi