381229-49-8

Basic information

• Product Name: (E)-1-(4-Acetyl-piperazin-1-yl)-3-(2,4-difluoro-phenyl)-propenone
• Synonyms: (E)-1-(4-Acetyl-piperazin-1-yl)-3-(2,4-difluoro-phenyl)-propenone
• CAS NO: 381229-49-8
• Molecular Weight: 294.301
• Mol File: 381229-49-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-(4-Acetyl-piperazin-1-yl)-3-(2,4-difluoro-phenyl)-propenone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(4-Acetyl-piperazin-1-yl)-3-(2,4-difluoro-phenyl)-propenone(381229-49-8)
• EPA Substance Registry System: (E)-1-(4-Acetyl-piperazin-1-yl)-3-(2,4-difluoro-phenyl)-propenone(381229-49-8)

Safety Data

• Hazardous Substances Data: 381229-49-8(Hazardous Substances Data)

Upstream product

• 94977-52-3 2,4-Difluorocinnamic acid 
• 13889-98-0 N-acetylpiperidine 
• 695186-78-8 trans 3-(2,4-difluorophenyl)-2-propenoic acid chloride 

Relevant articles and documents

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure - Activity relationship of substituents on the benzene ring of the cinnamide

We have shown that p-arylthio cinnamides can inhibit the interaction of LFA-1 and ICAM-1, which is involved in cell adhesion and the inflammatory process. We now show that 2,3-disubstitution on the aryl portion of the cinnamide results in enhanced activit