695186-78-8

Basic information

• Product Name: trans 3-(2,4-difluorophenyl)-2-propenoic acid chloride
• Synonyms: trans 3-(2,4-difluorophenyl)-2-propenoic acid chloride
• CAS NO: 695186-78-8
• Molecular Weight: 202.588
• Mol File: 695186-78-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: trans 3-(2,4-difluorophenyl)-2-propenoic acid chloride(CAS DataBase Reference)
• NIST Chemistry Reference: trans 3-(2,4-difluorophenyl)-2-propenoic acid chloride(695186-78-8)
• EPA Substance Registry System: trans 3-(2,4-difluorophenyl)-2-propenoic acid chloride(695186-78-8)

Safety Data

• Hazardous Substances Data: 695186-78-8(Hazardous Substances Data)

Upstream product

• 94977-52-3 2,4-Difluorocinnamic acid 

Downstream Products

• 862283-61-2 (4S)-4-benzyl-3-[(2E)-3-(2,4-difluorophenyl)prop-2-enoyl]-1,3-oxazolidin-2-one 
• 381229-49-8 (E)-1-(4-Acetyl-piperazin-1-yl)-3-(2,4-difluoro-phenyl)-propenone 

Relevant articles and documents

PIPERIDINOYL-PYRROLIDINE AND PIPERIDINOYL-PIPERIDINE COMPOUNDS

The present invention relates to a class of compounds of general formula (I) and the salts, hydrates, solvates, polymorphs and prodrugs wherein n, R6, R7 and R10 are as defined herein and especially to MCR4 agonist compounds of formula (I), to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

PHARMACEUTICALLY ACTIVE BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES

Compounds of formula (I): wherein R1, R2 and R3 are independently, hydrogen, halogen, CF3, OR6, NR7R8, NR8COR10, NR8SO2R10 or C1-6 alkyl optionally substituted by hydroxy, C1-6 alkoxy or NR7R8; R4 is NR8CONR8R9, NR8COR9, NR8SO2R9, or W-CONR8R9, where W is a bond, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene; and R5 is Formula (A) methods for their synthesis, pharmaceutical compositions comprising them and their use in medicine, in particular for the treatment of cancer.