381229-75-0Relevant academic research and scientific papers
GPR52 MODULATOR COMPOUNDS
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Page/Page column 54; 81-82, (2021/05/15)
The disclosures herein relate to novel compounds of Formula (1): (1) and salts thereof, wherein R1, Q, X, Y and Z are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure - Activity relationship of substituents on the benzene ring of the cinnamide
Winn,Kester,Von Geldern,Leitza,Devries,Dickinson,Mussatto,Okasinski,Reilly,Liu,Huth,Jae,Freeman,Pei,Xin,Lynch
, p. 4393 - 4403 (2007/10/03)
We have shown that p-arylthio cinnamides can inhibit the interaction of LFA-1 and ICAM-1, which is involved in cell adhesion and the inflammatory process. We now show that 2,3-disubstitution on the aryl portion of the cinnamide results in enhanced activit
