381230-33-7Relevant articles and documents
Novel carboxamide compound and compositions for preventing or treating metabolic diseases comprising the same
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Paragraph 0095-0099; 0126-0127; 0135-0136, (2021/09/14)
The present invention relates to a novel carboxamide compound and a composition for preventing or treating metabolic diseases comprising the same, wherein the composition is potent and selective estrogen related receptor (Estrogen-related receptor). ERR)
Solubility and solution thermodynamics of novel pyrazolo chalcone derivatives in various solvents from 298.15?K to 328.15?K
Baluja, Shipra,Hirapara, Asmita
, p. 692 - 704 (2019/01/10)
Some novel pyrazolo chalcone derivatives have been synthesized and characterization of these synthesized compounds was done by IR, 1H NMR, 13C NMR and mass analysis. The solubility of pyrazolo chalcone derivatives in methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol, ethyl acetate and acetonitrile was measured by gravimetric method over a temperature range (298.15 to 328.15) K at atmospheric pressure. The solubility of synthesized compounds is found to increase linearly with temperature. Further, in alcoholic solvents, solubility is maximum in 1-pentanol and minimum in methanol whereas in non-alcoholic solvents, solubility is greater in ethyl acetate and minimum in acetonitrile. The experimental solubility data were correlated with temperature by modified Apelblat and Buchowski-Ksiazczak λh equations. The experimental data and model parameters would be useful for optimizing the process of purification. Some thermodynamic parameters such as dissolution enthalpy, Gibb's free energy and entropy of mixing have also been calculated by Van't Hoff analysis. Further, excess enthalpy of solutions has been calculated using Buchowski-Ksiazczak λh equation.
Synthesis, Characterization, Molecular Docking Studies and Anticancer Activity of Schiff Bases Derived from 3-(Substituted phenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde and 2-Aminophenol
Wazalwar, Sachin S.,Banpurkar, Anita R.,Perdih, Franc
, p. 185 - 199 (2018/08/27)
Abstract: A series of new Schiff bases were synthesized by microwave assisted reactions of substituted 1-phenyl-1H-pyrazole-4-carbaldehyde and 2-aminophenol in ethanol and characterized by elemental analysis and spectroscopic (IR, 1H NMR and MS) data. The crystal structures of four compounds were studied using single-crystal XRD data. Molecular docking studies of all synthesized compounds were performed into the binding site of a protein 3GCW to gain comprehensive understanding into possible binding modes. These compounds were also screened for anticancer activity against the liver (HEP-G2) cell line using the sulphorhodamine-B assay method. Adriamycin i.e. doxorubicin was used as reference standard. One of the compounds shows anticancer activity close to the famous anticancer agent doxorubicin, which was used as control in this study. It is observed that all molecules show activity close to the standard in high concentrations only. Graphical Abstract: Present study describes the anticancer activity and crystal structure study of Schiff bases of substituted pyrazole-4-carbaldehyde with 2-aminophenol. Docking study of all compounds against human hepatoma cell line, HEP-G2 correlates with in vitro activity. [Figure not available: see fulltext.].
