3814-19-5

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(3-mercaptophenyl)is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a building block for the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, Ethanone, 1-(3-mercaptophenyl)- serves as an intermediate for the production of agrochemicals. Its role in this industry is crucial for the synthesis of compounds that help protect crops and enhance agricultural productivity.
Used in Fragrance Industry:
Ethanone, 1-(3-mercaptophenyl)is also employed as a fragrance ingredient. Its distinct aromatic properties make it a valuable component in the creation of various scent compositions used in perfumes, cosmetics, and other fragranced products.
Used in Polymer Production:
Ethanone, 1-(3-mercaptophenyl)finds application in the production of polymers, where it contributes to the development of materials with specific properties required for various applications in industries such as plastics, textiles, and coatings.
Used in Medical Research:
Ethanone, 1-(3-mercaptophenyl)has been studied for its potential therapeutic applications, particularly in the treatment of certain medical conditions like hypertension and inflammation. Its exploration in medical research underscores its versatility and potential impact on human health.

Upstream product

• 163630-12-4 (3-acetyl-phenylsulfanyl)-acetic acid 
• 140-89-6 potassium ethyl xanthogenate 
• 1052081-55-6 3-[(3-acetylphenyl)thio]propionic acid 2-ethylhexyl ester 
• 73035-16-2 3-acetylbenzene-1-sulfonyl chloride 
• 14452-30-3 3'-iodoacetophenone 
• 2142-63-4 1-(3-Bromophenyl)ethanone 

Downstream Products

• 40897-44-7 Di(m-acetylphenyl)disulfid 
• 94001-58-8 1-(3-methylsulfanyl-phenyl)-1-phenyl-ethanol 
• 1021157-58-3 1-[3-(cyclopentylthio)phenyl]ethanone 
• 89102-48-7 2-bromo-1-(3-mercaptophenyl)ethanone 
• 1351823-47-6 4-(5-bromothiophen-2-yl)-6-(3-(ethylthio)phenyl)-2,2'-bipyridine 
• 1351823-45-4 1-(2-(3-(ethylthio)phenyl)-2-oxoethyl)pyridinium iodide 
• 1351823-51-2 4-(5-(6-(3-(ethylthio)phenyl)-2,2'-bipyridin-4-yl)thiophen-2-yl)-N,N-bis(4-methoxyphenyl)aniline 
• 1351823-50-1 4-(5-(6-(3-(ethylthio)phenyl)-2,2'-bipyridin-4-yl)thiophen-2-yl)-N,N-diphenylaniline 
• 1052081-60-3 1-(3-(ethylthio)phenyl)ethanone 
• 1052081-65-8 3'-(4-nitrophenylthio)acetophenone 
• 1441-99-2 1-[3-(methylsulfanyl)phenyl]ethan-1-one 
• 19654-42-3 (m-Acetylphenyl)-N,N-dimethylthiocarbamat 

Relevant academic research and scientific papers

Discovery of 3,5-Dimethyl-4-Sulfonyl-1 H-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability

Myeloid cell leukemia 1 (Mcl-1) protein is a key negative regulator of apoptosis, and developing Mcl-1 inhibitors has been an attractive strategy for cancer therapy. Herein, we describe the rational design, synthesis, and structure-activity relationship study of 3,5-dimethyl-4-sulfonyl-1H-pyrrole-based compounds as Mcl-1 inhibitors. Stepwise optimizations of hit compound 11 with primary Mcl-1 inhibition (52%@30 μM) led to the discovery of the most potent compound 40 with high affinity (Kd = 0.23 nM) and superior selectivity over other Bcl-2 family proteins (>40,000 folds). Mechanistic studies revealed that 40 could activate the apoptosis signal pathway in an Mcl-1-dependent manner. 40 exhibited favorable physicochemical properties and pharmacokinetic profiles (F% = 41.3%). Furthermore, oral administration of 40 was well tolerated to effectively inhibit tumor growth (T/C = 37.3%) in MV4-11 xenograft models. Collectively, these findings implicate that compound 40 is a promising antitumor agent that deserves further preclinical evaluations.

SINGLE-STEP SYNTHESIS METHOD OF ARYL THIOL AND APPLICATION THEREOF

The present invention relates to a single-step synthesis method of aryl thiol, and more specifically, to a method of synthesizing aryl thiol in a single-step by making aryl halide react with alkane dithiol in the presence of a transition metal catalyst. According to the present invention, a single-step synthesis method using the transition metal catalyst, the synthesis method which is capable of synthesizing aryl thiol from aryl halide at a high yield, can be provided. Various aryl halides may be applied to the synthesis method. Further, the synthesis method has advantages that an easily usable reagent may be used, operations are simple, and reactions can be performed under mild conditions. In addition, the synthesized aryl thiol may be used in the synthesis of advanced molecules such as diaryl sulfides and benzothiophenes.COPYRIGHT KIPO 2017

Copper(II)-Catalyzed Single-Step Synthesis of Aryl Thiols from Aryl Halides and 1,2-Ethanedithiol

A highly efficient transition metal-catalyzed single-step synthesis of aryl thiols from aryl halides has been developed employing copper(II) catalyst and 1,2-ethanedithiol. The key features are use of readily available reagents, a simple operation, and relatively mild reaction conditions. This new protocol shows a broad substrate scope with excellent functional group compatibility. A variety of aryl thiols are directly prepared from aryl halides in high yields. Furthermore, the aryl thiols are used in situ for the synthesis of more advanced molecules such as diaryl sulfides and benzothiophenes.

Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis

Abstract The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel present in the membrane of epithelial cells. Mutations affecting the CFTR gene cause cystic fibrosis (CF), a multi-organ severe disease. The most common CF mutation, F508del, impairs the processing and activity (gating) of CFTR protein. Other mutations, like G551D, only cause a gating defect. Processing and gating defects can be targeted by small molecules called generically correctors and potentiators, respectively. Aminoarylthiazoles (AATs) represent an interesting class of compounds that includes molecules with dual activity, as correctors and potentiators. With the aim to improve the activity profile of AATs, we have now designed and synthesized a library of novel compounds in order to establish an initial SAR that may provide indications about the chemical groups that are beneficial or detrimental for rescue activity. The new compounds were tested as correctors and potentiators in CFBE41o-expressing F508del-CFTR using a functional assay. A dual active compound, AAT-4a, characterized by improved efficacy and marked synergy when combined with the corrector VX-809 has been identified. Moreover, by computational methods, a possible binding site for AATs in nucleotide binding domain NBD1 has been detected. These results will direct the synthesis of new analogues with possibly improved activity.

Regioselective C-H activation of cyclometalated bis-tridentate ruthenium complexes

A series of bis-tridentate Ru(II) complexes consisting of trimethyl-4,4′,4″-tricarboxylate-2,2′:6′, 2″-terpyridine (Me3tctpy) and derivatized 6-phenyl-2,2′- bipyridine (pbpy) ligands are reported. Each complex is attached to a terminal tripheny

A simple, fast and chemoselective method for the preparation of arylthiols

An efficient and convenient method for the synthesis of arylthiols by reaction of sulfonyl chlorides with triphenylphosphine in toluene is reported.

NOVEL PYRROLE DERIVATIVE HAVING UREIDE GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS

Objects of the present invention are to study on the synthesis of a novel pyrrole derivative having a ureido group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or a salt thereof, and to f

DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE β2 ADRENERGIC RECEPTOR

The present invention provides a Compound of formula (I), wherein: R1 is a group selected from -CH2OH,-NH(CO)H; and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH-, wherei

Oxidative cleavage of S-Arylmercaptoacetic acids by pyridinium chlorochromate: Kinetic and correlation analysis

Kinetics of oxidation of 24 S-Arylmercaptoacetic acids (SAMA) by pyridinium chlorochromate (PCC) have been studied in acid medium. The product of oxidation is the corresponding thiophenol. The rate data of meta- and para-substituted acids have been correlated well with σI, σ°R values and the meta-compounds correlate well with F,R values. The reaction constants are negative and of smaller magnitudes. Further, the ortho-substituted acids show a good correlation with triparametric equation involving Taft's σI and σ°R and charton's steric parameter v. There is no considerable steric contribution to the total orthosubstituent effect. Based on these observations, the mechanism involving the formation of protonated arylsulfinylacetic acid intermediate, followed by an intramolecular rearrangement leading to the product thiophenol has been proposed.

Oxidative Cleavage of S-Arylmercaptoacetic Acids by Sodium Perborate: Kinetic and Correlation Study

Kinetics of oxidation of twenty six S-arylmercaptoacetic acids (SAMA) (I) by sodium perborate (PB) have been studied in acid medium.The product of oxidation is the corresponding thiophenol.The rate data of meta- and para-substituted acids have been correlated with DSP equations.While the para-compounds correlate well with ?I and ?0R values, the meta-compounds correlate well with ?I and ?-R values.The reaction constants are negative and of smaller magnitudes.Further, the ortho-substituted acids show a good correlation with a triparametric equation involving Taft's ?I and ?0R and Charton's steric parameter ν.There is a considerable steric contribution to the total ortho-substituent effect.Based on these observations, mechanism involving the formation of protonated arylsulfinylacetic acid intermediate, followed by an intramolecular rearrangement leading to the product thiophenol has been proposed.