381665-53-8

Upstream product

• 490021-17-5 (E)-(R)-5-(4-Methoxy-benzyloxy)-6-methyl-hepta-2,6-dienoic acid ethyl ester 
• 490021-18-6 tert-Butyl-[(1R,3R)-1-ethynyl-3-(4-methoxy-benzyloxy)-4-methyl-pent-4-enyloxy]-dimethyl-silane 
• 381665-43-6 (R)-6-[(E)-(3R,4R,6R)-6-Hydroxy-4-(4-methoxy-benzyloxy)-3-methyl-3-triethylsilanyloxy-8-trimethylsilanyl-oct-1-en-7-ynyl]-5,6-dihydro-pyran-2-one 
• 381665-42-5 (R)-6-[(E)-(3R,4R)-4-(4-Methoxy-benzyloxy)-3-methyl-6-oxo-3-triethylsilanyloxy-8-trimethylsilanyl-oct-1-en-7-ynyl]-5,6-dihydro-pyran-2-one 
• 381665-50-5 (E)-(2R,3R)-5-((2R,6R)-6-Isopropoxy-3,6-dihydro-2H-pyran-2-yl)-3-methyl-3-triethylsilanyloxy-1-(2-trimethylsilanylethynyl-[1,3]dithian-2-yl)-pent-4-en-2-ol 
• 381665-41-4 (R)-6-[(E)-(3R,4R)-4-Hydroxy-3-methyl-3-triethylsilanyloxy-5-(2-trimethylsilanylethynyl-[1,3]dithian-2-yl)-pent-1-enyl]-5,6-dihydro-pyran-2-one 
• 381665-51-6 (R)-6-((E)-(3R,4R)-4-Hydroxy-3-methyl-6-oxo-3-triethylsilanyloxy-8-trimethylsilanyl-oct-1-en-7-ynyl)-5,6-dihydro-pyran-2-one 
• 381665-49-2 Triethyl-[(E)-(R)-3-((2R,6R)-6-isopropoxy-3,6-dihydro-2H-pyran-2-yl)-1-methyl-1-(R)-oxiranyl-allyloxy]-silane 
• 381665-40-3 (E)-(R)-4-((2R,6R)-6-Isopropoxy-3,6-dihydro-2H-pyran-2-yl)-2-(R)-oxiranyl-but-3-en-2-ol 
• 381665-39-0 (2R,6R)-6-Benzyloxy-2-ethynyl-3,6-dihydro-2H-pyran 
• 381665-48-1 (2R,6R)-2-ethynyl-6-isopropoxy-3,6-dihydro-2H-pyran 
• 994-30-9 triethylsilyl chloride 
• 490021-14-2 Acrylic acid (E)-(1R,4R,5R,7R)-1-allyl-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4-methyl-4-triethylsilanyloxy-non-2-en-8-ynyl ester 
• 490021-02-8 (R)-3-(4-Methoxy-benzyloxy)-4-methyl-pent-4-enoic acid ethyl ester 

Downstream Products

• 381665-45-8 (6R)-6-{(1E,3R,4R,6R,7Z,9Z,11E)-6-{[tert-butyl(dimethyl)silyl]oxy}-13-{[tert-butyl(diphenyl)silyl]oxy}-4-hydroxy-3-methyl-3-[(triethylsilyl)oxy]trideca-1,7,9,11-tetraen-1-yl}-5,6-dihydro-2H-pyran-2-one 

Relevant academic research and scientific papers

Synthesis and structure - Activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8- methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents

A series of novel 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolones bearing fluorinated (3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl substituents at the C-7 position (2-4) was synthesized to obtain potent drugs for infections cau

Formal Total Synthesis of Fostriecin

(Matrix Presented) Addition of magnesium anion 4 (M = MgBr, R1 = TES) to ketone 6 (R2 = PMB) at -78°C in THF proceeded under chelation control to provide alcohol 7, which possesses the full set of the chiral centers of fostriecin. Su

Total synthesis of fostriecin (CI-920)

The most selective protein phosphatase inhibitor identified to date, fostriecin was synthesized in a highly convergent manner by a chiral building block approach (see picture). Three of the four stereocenters were introduced by using catalytic methods, in