381670-43-5Relevant articles and documents
Solution-phase synthesis of short oligo-2'-deoxyribonucleotides by using clustered nucleosides as a soluble support
Kungurtsev, Vyacheslav,Laakkonen, Jouni,Molina, Alejandro Gimenez,Virta, Pasi
, p. 6687 - 6693 (2013)
5'-O-(4,4'-Dimethoxytrityl)thymidine was attached to a pentaerythrityl- derived core, and the resulting tetravalent nucleoside cluster and the next dendritic generations served as a soluble support for the synthesis of short oligo-2'-deoxyribonucleotides
Synthesis of Size-Tunable Hollow Polypyrrole Nanostructures and Their Assembly into Folate-Targeting and pH-Responsive Anticancer Drug-Delivery Agents
Chen, Jian,Li, Xiufang,Sun, Yanhua,Hu, Yuwei,Peng, Yulong,Li, Yimin,Yin, Gang,Liu, Hui,Xu, Jiangfeng,Zhong, Shian
supporting information, p. 17279 - 17289 (2017/11/20)
Chemotherapeutic drugs currently used in clinical settings have high toxicity, low specificity, and short half-lives. Herein, polypyrrole-based anticancer drug nanocapsules were prepared by tailoring the size of the nanoparticles with a template method, controlling drug release by means of an aromatic imine, increasing nanoparticle stability through PEGylation, and improving tumor-cell selectivity by folate mediation. The nanoparticles were characterized by TEM and dynamic light scattering. α-Folate receptor expression levelsof tumor cells and normal cells were investigated by western blot and quantitative polymerase chain reaction analyses. Flow cytometry and fluorescence imaging were used to verify the cell uptake of the different-sized nanoparticles. From the different-sized polypyrrole nanoparticles, the optimally functionalized nanoparticles of 180 nm hydrodynamic diameter were chosen and further usedfor in vitroandin vivotests. The nanoparticles showed excellent biocompatibility and the drug-loaded nanoparticles exhibited effective inhibition of tumor cell growth in vitro. Moreover, the drug-loaded nanoparticles showed substantially enhanced accumulation in tumor regions and effectively inhibitedin vivotumor growth. Furthermore, the nanoparticles showed reduced doxorubicin-induced toxicity andno significant side effects in normal organs of tumor-bearing mice, as measured by body-weight shifts and evaluationof drug distribution. Overall, the functionalized nanoparticles are promising nanocarriers for tumor-targeting drug delivery.
Synthesis of soluble core cross-linked polystyrene star polymer by application of acrylate-nitrile oxide 'click chemistry' using metal-free reagents
Banerjee, Rakesh,Maiti, Saikat,Dhara, Dibakar
, p. 1365 - 1373 (2014/03/21)
In the present work, we have established a novel and environmentally benign method, whereby a 1,3-dipolar cycloaddition reaction has been applied using a non-toxic reagent, iodosobenzenediacetate [PhI(OAc)2], instead of the conventional copper-based reagents for the development of star-branched polymers. Here we have demonstrated the synthesis of core cross-linked star (CCS) polymers via the formation of isoxazoline ring using 'click reaction' between acrylate functionalities in a polymer chain and in situ generated nitrile oxide groups from a cross-linker added externally. In the initial step, a well-defined styrenic block copolymer with acrylate-functionalized middle-block was synthesized by controlled radical polymerization (RAFT) using α,α′-xylyl-bis(dithiobenzoate) as a chain transfer agent using 4-vinyl benzyl chloride and styrene as comonomers. Thereafter, the chlorobenzyl groups were converted into acrylate by reaction with acrylic acid. In the following step, core cross-linked star (CCS) polymers were synthesized by reacting the above block copolymer and oxime-functionalized cross-linkers (bi- and tetra-functional) using PhI(OAc)2 'click chemistry'. Formation of CCS polymers was confirmed from NMR, FTIR, GPC and DLS studies.
