381675-07-6

Upstream product

• 85-44-9 phthalic anhydride 
• 13116-27-3 4-iodophenylhydrazine 

Downstream Products

• 880488-57-3 2-(4-Phenylsulfanyl-phenyl)-2,3-dihydro-phthalazine-1,4-dione 
• 880488-23-3 2-biphenyl-4-yl-4-hydroxy-2H-phthalazin-1-one 

Relevant academic research and scientific papers

Methods of inhibiting BTK and SYK protein kinases

Methods of inhibiting a tyrosine kinase wherein said tyrosine kinase is BTK or SYK comprising administering to a patient in need thereof a therapeutically effective amount of a compound according to formula I are disclosed. The compounds are useful for treating auto-immune and inflammatory diseases.

NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.