880488-57-3

Upstream product

• 381675-07-6 4-Hydroxy-2-(4-iodophenyl)-2H-phthalazin-1-one 
• 108-98-5 thiophenol 

Downstream Products

• 880488-58-4 4-Bromo-2-(4-phenylsulfanyl-phenyl)-2H-phthalazin-1-one 

Relevant academic research and scientific papers

Methods of inhibiting BTK and SYK protein kinases

Methods of inhibiting a tyrosine kinase wherein said tyrosine kinase is BTK or SYK comprising administering to a patient in need thereof a therapeutically effective amount of a compound according to formula I are disclosed. The compounds are useful for treating auto-immune and inflammatory diseases.

NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.