38176-02-2

Basic information

• Product Name: (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride
• Synonyms: R(+)-VERAPAMIL MONOHYDROCHLORIDE MONOHYDRATE;Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (aR)- (9CI);Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (R)-;Dexverapamil monohydrochloride;LU 33925;NSC 632821;Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (alphaR)-;Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]-methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (R)-
• CAS NO: 38176-02-2
• Molecular Formula: C27H41ClN2O5
• Molecular Weight: 509.07784
• EINECS: 253-810-3
• Product Categories: Drug Efflux Pumps;Modulators for MDR/TAP Transporters;Multi-Drug Resistance;Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 38176-02-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 129-131?C
• Appearance: white/
• Storage Temp.: Refrigerator
• Solubility: H2O: >30mg/mL
• CAS DataBase Reference: (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride(38176-02-2)
• EPA Substance Registry System: (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride(38176-02-2)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 22-36/37/39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 38176-02-2(Hazardous Substances Data)

Usage

Chemical Properties

Colourless solid

Uses

R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.

Biochem/physiol Actions

Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.

InChI:InChI=1/C26H36N2O4.ClH/c1-7-26(19-27,21-12-13-22(29-3)24(18-21)31-5)15-9-16-28(2)17-14-20-10-8-11-23(30-4)25(20)32-6;/h8,10-13,18H,7,9,14-17H2,1-6H3;1H