38176-10-2

Basic information

• Product Name: R(+)-VERAPAMIL HYDROCHLORIDE
• Synonyms: R(+)-VERAPAMIL HYDROCHLORIDE;(+)-VERAPAMIL, METHOXY-, HYDROCHLORIDE;(+)-METHOXYVERAPAMIL HYDROCHLORIDE
• CAS NO: 38176-10-2
• Molecular Formula: C₂₈H₄₀N₂O₅
• Molecular Weight: 491.06
• Mol File: 38176-10-2.mol
• Article Data: 2

Chemical Properties

• Appearance: white/solid
• Solubility: H2O: >30 mg/mL
• CAS DataBase Reference: R(+)-VERAPAMIL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: R(+)-VERAPAMIL HYDROCHLORIDE(38176-10-2)
• EPA Substance Registry System: R(+)-VERAPAMIL HYDROCHLORIDE(38176-10-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 38176-10-2(Hazardous Substances Data)

Upstream product

• 3490-06-0 N-methylhomoveratrylamine 
• 116759-58-1 Methanesulfonic acid (R)-4-cyano-5-methyl-4-(3,4,5-trimethoxy-phenyl)-hexyl ester 
• 16662-47-8 gallopamil 
• 107173-91-1 (2R,3R)-(-)-1-<(methylsulfonyl)oxy>-2-methyl-3-cyano-3-(3,4,5-trimethoxyphenyl)hex-5-ene 
• 107149-02-0 (2R,3R)-(-)-2-methyl-3-cyano-3-(3,4,5-trimethoxyphenyl)hex-5-enol 
• 38532-60-4 (4R)-(+)-4-cyano-4-(3,4,5-trimethoxyphenyl)-4-isopropylbutanol 
• 107149-00-8 (2R,3R)-(+)-2-(2-propenyl)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone 
• 107149-05-3 (4R)-(-)-4-cyano-4-(3,4,5-trimethoxyphenyl)-4-isopropylbutene 
• 107148-95-8 (2S,3R)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 13230-71-2 N-[2-(3,4-dimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide 

Downstream Products

• 107149-08-6 N-<(2R)-2-(3,4,5-trimethoxyphenyl)-2-isopropyl-5-<(3,4-dimethoxyphenethyl)methylamino>pentyl>-(1S)-10-camphorsulfonamide 
• 107149-09-7 (R)-N¹-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-isopropyl-N¹-methyl-4-(3,4,5-trimethoxy-phenyl)-pentane-1,5-diamine 

Relevant articles and documents

Chiral separation of calcium channel antagonists by SFC and HPLC using different immobilized chiral stationary phases

Supercritical fluid chromatography and high-performance liquid chromatography techniques are popular for the chiral separations of different drugs and pharmaceuticals. Therefore, this article describes a comparative study of the chiral separation of some calcium channel antagonists such as verapamil, gallopamil, and nisoldipine. The columns used were Chiralpak IG and Chiralpak ID (250 mm × 4.6?mm, 5.0?μm). The separation was achieved by using a variety of mobile phases in both techniques. The retention, separation, and resolution factors in SFC were in the range of 1.36–7.30, 1.09–1.72, and 1.16–3.47, while these values in the case of HPLC were 1.03–2.42, 1.12–1.35, and 0.49–2.46. The complete resolution of gallopamil and verapamil was achieved successfully. The chiral recognition was controlled by hydrogen bondings, π-π interactions, dipole induced dipole interactions, van der Waal forces, and steric effects. SFC was found to be a better technique than HPLC because of quick separation, good separation power, economic, environment-friendly, and green technology.