38177-86-5Relevant academic research and scientific papers
Syntheses of trifluoroethylated unsymmetrical 1,3-diynes by using 1,1-dichloro-2,2,2-trifluoroethane
Zheng, Jian,Chen, Qing-Yun,Sun, Ke,Huang, Yangen,Guo, Yong
, p. 5757 - 5760 (2016/12/06)
Copper-mediated reaction of terminal 1,3-diynes with 1,1-dichloro-2,2,2-trifluoroethane (CF3CHCl2) using ethanolamine as ligand gave trifluoroethylated unsymmetrical 1,3-diynes in moderate to good yields. The reaction were carried out under mild conditions, and were easy to operate. Aryl groups with weak electron-withdrawing group or electron-donating group, and alkyl substitutents at terminal 1,3-diynes were tolerated. Synthesis of a trifluoroethylated conjugated triyne by using this method was demonstrated. Further transformation of the trifluoroethylated unsymmetrical 1,3-diyne to provide trifluoroethyl-substituted 1,2,3-triazole and isoxazole as application examples were successfully realized.
Highly enantioselective copper(i)-catalyzed conjugate addition of 1,3-diynes to α,β-unsaturated trifluoromethyl ketones
Sanz-Marco, Amparo,Blay, Gonzalo,Mu?oz, M. Carmen,Pedro, José R.
supporting information, p. 8958 - 8961 (2015/05/27)
The conjugate diynylation of α,β-unsaturated trifluoromethyl ketones is carried out in the presence of a low catalytic load (2.5 mol%) of a copper(i)-MeOBIPHEP complex, triethylamine and a terminal 1,3-diyne. Pre-metalation of the terminal 1,3-diyne with stoichiometric or higher amounts of dialkylzinc reagent is not required. The corresponding internal diynes bearing a propargylic stereogenic center are obtained with good yields and excellent enantioselectivities. This journal is
Air-stable (phenylbuta-1,3-diynyl)palladium(II) complexes: Highly active initiators for living polymerization of isocyanides
Xue, Ya-Xin,Zhu, Yuan-Yuan,Gao, Long-Mei,He, Xiao-Yue,Liu, Na,Zhang, Wu-Yi,Yin, Jun,Ding, Yunsheng,Zhou, Hongping,Wu, Zong-Quan
, p. 4706 - 4713 (2014/04/17)
A family of air-stable (phenylbuta-1,3-diynyl)palladium(II) complexes were designed and prepared in a facile synthetic procedure. Their structures were characterized by 1H and 13C NMR, MS, and X-ray analysis. These Pd complexes were
Gold-catalyzed oxidative cross-coupling of terminal alkynes: Selective synthesis of unsymmetrical 1,3-diynes
Peng, Haihui,Xi, Yumeng,Ronaghi, Nima,Dong, Boliang,Akhmedov, Novruz G.,Shi, Xiaodong
, p. 13174 - 13177 (2015/03/30)
Gold-catalyzed oxidative cross-coupling of alkynes to unsymmetrical diynes has been achieved for the first time. A N,N-ligand (1,10-Phen) and PhI(OAc)2 were identified as crucial factors to promote this transformation, giving the desired cross-
Zinc-mediated enantioselective addition of terminal 1,3-diynes to N-arylimines of trifluoropyruvates
Zhang, Fa-Guang,Ma, Hai,Zheng, Yan,Ma, Jun-An
scheme or table, p. 7663 - 7669 (2012/09/05)
A facile and effective enantioselective addition of terminal 1,3-diynes to acyclic α-CF3 ketimine esters has been developed by using zinc/Binol complexes. The reaction works well with a variety of aromatic-, aliphatic- and silyl-substituted diynes, providing the desired products in up to 97% yield and 97% enantiomeric excess.
Regioselective trapping of terminal di-, tri-, and tetraynes with benzyl azide
Luu, Thanh,McDonald, Robert,Tykwinski, Rik R.
, p. 6035 - 6038 (2007/10/03)
(Chemical Equation Presented) The reaction of benzyl azide with terminal di-, tri-, and tetraynes appended with a range of functional groups has been explored. Standard reaction conditions for BnN3 catalyzed by CuSO4·5H2O
