38179-53-2Relevant academic research and scientific papers
Chiral Sulfide Catalysis for Desymmetrizing Enantioselective Chlorination
Cao, Qingxiang,Luo, Jie,Zhao, Xiaodan
, p. 1315 - 1319 (2019)
An unprecendented chiral sulfide catalyzed desymmetrizing enantioselective chlorination is disclosed. Various aryl-tethered diolefins and diaryl-tethered olefins afforded teralins and tricyclic hexahydrophenalene derivatives, respectively, bearing multiple stereogenic centers in high yields with excellent enantio- and diastereoselectivities. In contrast, the tertiary amine catalyst (DHQD)2PHAL led to a diastereomeric product. The products could be transformed into a variety of compounds, such as spiro-N-heterocycles.
