3818-24-4Relevant academic research and scientific papers
THE UTILITY OF SILICON IN ORGANIC SYNTHESIS ANNULATION METHODOLOGY AND APPLICATIONS EMPLOYING α-TRIMETHYLSILYL VINYL KETONES
Boeckman, Robert K.
, p. 925 - 934 (2007/10/02)
New annulation methodology based upon the addition of diorganocuprates to α,β-unsaturated ketones and regiospecific trapping of the resulting enolate with α-trimethylsilyl vinyl ketones is presented.The stereochemical details of the process have been elucidated and are discussed.Application of this methodology to the synthesis of a variety of polycyclic ketone structures is described including applications to steroid synthesis.
