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3-hydroxy-2,2-bis(hydroxymethyl)propionaldehyde, commonly known as Dihydroxyacetone (DHA), is a simple carbohydrate that is widely recognized for its role in sunless tanning products. It is a colorless compound that safely interacts with the amino acids in dead skin cells, leading to a brown color change. DHA has been deemed safe for external use and has received approval from the Food and Drug Administration (FDA) for its inclusion in cosmetic products, particularly those designed for sunless tanning. However, it is important to note that excessive application or contact with sensitive areas such as the eyes or mouth may result in skin irritation.

3818-32-4

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3818-32-4 Usage

Uses

Used in Cosmetic Industry:
3-hydroxy-2,2-bis(hydroxymethyl)propionaldehyde is used as an active ingredient in sunless tanning products for its ability to mimic the natural tanning process. It achieves this by interacting with the amino acids in dead skin cells, resulting in a temporary brown color change that gives the skin a tanned appearance without the need for exposure to ultraviolet (UV) radiation.
Used in Skincare Products:
3-hydroxy-2,2-bis(hydroxymethyl)propionaldehyde is used as a skin care component for its moisturizing properties. 3-hydroxy-2,2-bis(hydroxymethyl)propionaldehyde's hydroxyl groups can form hydrogen bonds with water molecules, helping to retain moisture in the skin and providing a hydrating effect.
Used in Pharmaceutical Industry:
While not explicitly mentioned in the provided materials, 3-hydroxy-2,2-bis(hydroxymethyl)propionaldehyde, given its chemical properties, could potentially be used in the pharmaceutical industry for various applications, such as a starting material for the synthesis of other compounds or as a component in topical formulations. However, further research and regulatory approval would be required to establish its use in this context.

Check Digit Verification of cas no

The CAS Registry Mumber 3818-32-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,1 and 8 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3818-32:
(6*3)+(5*8)+(4*1)+(3*8)+(2*3)+(1*2)=94
94 % 10 = 4
So 3818-32-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H10O4/c6-1-5(2-7,3-8)4-9/h1,7-9H,2-4H2

3818-32-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Hydroxy-2,2-bis(hydroxymethyl)propanal

1.2 Other means of identification

Product number -
Other names 3-hydroxy-2,2-bis-hydroxymethyl-propionaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3818-32-4 SDS

3818-32-4Synthetic route

formaldehyd
50-00-0

formaldehyd

acetaldehyde
75-07-0

acetaldehyde

tri(hydroxymethyl)acetaldehyde
3818-32-4

tri(hydroxymethyl)acetaldehyde

Conditions
ConditionsYield
With sodium hydroxide; water
With sodium carbonate at 40 - 50℃;
With sodium carbonate at 40 - 50℃;
2-dimethoxymethyl-2-hydroxymethyl-propane-1,3-diol
40364-88-3

2-dimethoxymethyl-2-hydroxymethyl-propane-1,3-diol

tri(hydroxymethyl)acetaldehyde
3818-32-4

tri(hydroxymethyl)acetaldehyde

Conditions
ConditionsYield
With sulfuric acid
formaldehyd
50-00-0

formaldehyd

acetaldehyde
75-07-0

acetaldehyde

A

Pentaerythritol
115-77-5

Pentaerythritol

B

tri(hydroxymethyl)acetaldehyde
3818-32-4

tri(hydroxymethyl)acetaldehyde

C

Dipentaerythritol
126-58-9

Dipentaerythritol

D

tripentaerythritol
78-24-0

tripentaerythritol

E

3-(3-Hydroxy-2,2-bis-hydroxymethyl-propoxy)-2,2-bis-hydroxymethyl-propionaldehyde

3-(3-Hydroxy-2,2-bis-hydroxymethyl-propoxy)-2,2-bis-hydroxymethyl-propionaldehyde

F

3-[3-(3-Hydroxy-2,2-bis-hydroxymethyl-propoxy)-2,2-bis-hydroxymethyl-propoxy]-2,2-bis-hydroxymethyl-propionaldehyde

3-[3-(3-Hydroxy-2,2-bis-hydroxymethyl-propoxy)-2,2-bis-hydroxymethyl-propoxy]-2,2-bis-hydroxymethyl-propionaldehyde

Conditions
ConditionsYield
With sodium hydroxide at 30℃; Product distribution; Mechanism; pH=12.5; different initial acetaldehyde concentrations;
dimethoxymethyl-hydroxymethyl-malonic acid dimethyl ester
40364-87-2

dimethoxymethyl-hydroxymethyl-malonic acid dimethyl ester

tri(hydroxymethyl)acetaldehyde
3818-32-4

tri(hydroxymethyl)acetaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4 / diethyl ether
2: aq. H2SO4
View Scheme
Pentaerythritol
115-77-5

Pentaerythritol

tri(hydroxymethyl)acetaldehyde
3818-32-4

tri(hydroxymethyl)acetaldehyde

Conditions
ConditionsYield
With potassium nitrate at 298.2℃; Kinetics; Catalytic behavior; Mechanism; Temperature; Alkaline conditions;
formaldehyd
50-00-0

formaldehyd

tri(hydroxymethyl)acetaldehyde
3818-32-4

tri(hydroxymethyl)acetaldehyde

aqueous NaOH-solution

aqueous NaOH-solution

Pentaerythritol
115-77-5

Pentaerythritol

Conditions
ConditionsYield
at 0 - 41℃; Rate constant;
tri(hydroxymethyl)acetaldehyde
3818-32-4

tri(hydroxymethyl)acetaldehyde

water
7732-18-5

water

triacetate of tris-hydroxymethyl-acetaldehyde

triacetate of tris-hydroxymethyl-acetaldehyde

3818-32-4Downstream Products

3818-32-4Relevant academic research and scientific papers

Kinetics and mechanism of oxidation of pentaerythritol by ditelluratoargentate(iii) in alkaline medium

Shanjinhuan,Yincaihong,Biangang,Liuyanping

, p. 1698 - 1700 (2013/09/24)

The kinetics of oxidation of pentaerythritol by ditelluratoargentate (III) (DTA) in alkaline liquids has been studied spectrophotometrically in the temperature range of 293.2 K-313.2 K. The reaction rate showed first-order dependence in DTA and fractional order with respect to pentaerythritol. It was found that the pseudo-first-order rate constant kobs increased with an increase in concentration of OH- and a decrease in concentration of H4TeO6 2-. There was a negative salt effect and no free radicals were detected. A plausible mechanism involving a two-electron transfer is proposed and the rate equations derived from the mechanism can explain all the experimental results. The rate equations derived from mechanism can explain all experimental observations. The activation parameters along with the rate constants of the rate-determining step were calculated.

ANALYSIS OF THE STRUCTURE OF THE REACTION SYSTEM OF A PROCESS ON THE BASIS OF INTEGRAL CHARACTERISTICS.

Belkin

, p. 341 - 345 (2007/10/02)

In this work the structure of the reactions of the acetaldehyde-formaldehyde condensation process is subjected to systems analysis, based on the dependence of its integral characteristics on the general conditions, and the main routes of detailed experimental verification of the proposed mechanism are suggested.

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