38186-54-8Relevant academic research and scientific papers
Synthesis of substituted 4-([1,2,4]triazolo[3,4-b]-[1,3,4]thiadiazol-6-yl) quinolines
Obushak,Pokhodylo,Krupa,Matiichuk
, p. 1223 - 1227 (2007)
4-Amino-5-R1-4H-1,2,4-triazole-3-thiols react with 2-R 2-6-R3-quinoline-4-carboxylic acids in phosphoryl chloride to give 2-R2-6-R3-4-(3-R1-[1,2,4]triazolo[3,4- b][1,3,4]thiadiazol-6-yl)qui
Phosphatase Binding Compounds and Methods of Using Same
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Page/Page column 2; 232; 236, (2020/07/25)
The present invention provides bifunctional compounds that efficiently dephosphorylate certain phospho-activated target proteins. Such target proteins can be any protein involved in the pathway of a disease or disorder, such as but not limited to cancer, neurodegeneration, metabolic disease, diabetes, insulin resistance, and so forth.
Synthesis and Luminescent Properties of Eu3+, Gd3+, and Tb3+ Complexes with Quinoline-4-carboxylic Acids
Aksenov, N. A.,Aksenova, I. V.,Dotsenko, V. V.,Kolokolov, F. A.,Kotlova, I. A.
, p. 2413 - 2419 (2020/02/25)
New complex compounds LnL3·nH2O (n = 5–10) have been synthesized on the basis of Eu3+, Gd3+, and Tb3+ salts and quinoline-4-carboxylic acid derivatives obtained via the Pfitzinger reaction. Compositio
A simple one-pot synthesis of quinoline-4-carboxylic acid derivatives by Pfitzinger reaction of isatin with ketones in water
Lv, Qinghua,Fang, Lizhen,Wang, Pengfei,Lu, Chenjuan,Yan, Fulin
, p. 391 - 394 (2013/05/21)
An improved Pfitzinger condensation reaction performed under acidic conditions is established. It provides a simple and efficient synthetic method for some useful quinoline-4-carboxylic acid derivatives using isatins and ketones that cannot be obtained ea
Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors
Wu, Yiran,Chen, Zheng,Liu, Ying,Yu, Lanlan,Zhou, Lu,Yang, Suijia,Lai, Luhua
experimental part, p. 3361 - 3366 (2011/07/29)
A series of novel fused heterocycle methyl esters were designed and synthesized as human nonpancreatic secretory phospholipase A2 (hnps-PLA2) competitive inhibitors. Among the 22 synthesized compounds, 17 quinoline-4-methyl esters displayed hnps-PLA2 inhibition activity in the in vitro bioassay. The IC50 value for the best compound 3o was 1.5 μM. The structure-inhibition-activity relationships of the compounds were studied using molecular docking.
Microwave-assisted synthesis of quinoline derivatives from isatin
El Ashry, El Sayed H.,Ramadan, El Sayed,Hamid, Hamida Abdel,Hagar, Mohamed
, p. 2243 - 2250 (2007/10/03)
Microwave irradiation has been used for a rapid and efficient synthesis of quinoline-4-carboxylic acids 5a-g and 1,2,3,4-tetrahydroacridine-9-carboxylic acid (6) from the reaction of isatins 1-3 with acyclic and cyclic ketones in basic medium. 2-Hydroxyquinoline-4-carboxylic acid (11) was also obtained by irradiating a mixture of isatin 1 and malonic acid in AcOH. The esters of 5f and 11 and their respective hydrazides 8 and 13 were also prepared under MWI. Copyright Taylor & Francis, Inc.
Synthesis of substituted quinoline-4-carboxylic acids
Lackey,Sternbach
, p. 993 - 997 (2007/10/02)
A high yielding synthesis of a variety of quinoline-4-carboxylic acids has been accomplished using a modified Pfitzinger approach involving the condensation of a ketone with an isatin derivative employing aqueous acid conditions. A convenient synthesis of
