38192-14-2

Usage

Uses

Used in Rubber and Plastics Industry:
Bis(m-chlorobenzo)hydrazide is used as a crosslinking agent to enhance the strength and durability of rubber and plastic products. Its ability to form covalent bonds between polymer chains contributes to the improved mechanical properties of these materials.
Used in Agriculture and Industry:
Bis(m-chlorobenzo)hydrazide is used as an anti-bacterial and anti-fungal agent in various applications. Its biocidal properties help control the growth of harmful microorganisms, thereby preventing spoilage and contamination in agricultural products and industrial processes.
Used in Metal Coating Industry:
Bis(m-chlorobenzo)hydrazide has potential as a corrosion inhibitor in metal coatings. Its ability to form protective layers on metal surfaces can help prevent corrosion and extend the service life of metal components.
Safety Precautions:
When handling bis(m-chlorobenzo)hydrazide, it is crucial to use personal protective equipment, such as gloves, goggles, and masks, to prevent skin and eye irritation. Proper ventilation should also be maintained to minimize the risk of inhalation. In case of accidental ingestion or inhalation, immediate medical attention should be sought.

InChI:InChI=1/C14H10Cl2N2O2/c15-11-5-1-3-9(7-11)13(19)17-18-14(20)10-4-2-6-12(16)8-10/h1-8H,(H,17,19)(H,18,20)

Upstream product

• 1128-76-3 3-chloro-benzoic acid ethyl ester 
• 1673-47-8 3-chlorobenzhydrazide 
• 618-46-2 m-Chlorobenzoyl chloride 

Downstream Products

• 1428432-42-1 7-chloro-3,4-diphenylisoquinolin-1(2H)-one 
• 100677-40-5 3,5-bis(3-chlorophenyl)-1H-1,2,4-triazole 
• 17452-96-9 2,5-bis-(3-chloro-phenyl)-[1,3,4]thiadiazole 
• 2639-17-0 2,5-bis-(m-chlorophenyl)-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Rapid and Atom Economic Synthesis of Isoquinolines and Isoquinolinones by C–H/N–N Activation Using a Homogeneous Recyclable Ruthenium Catalyst in PEG Media

Herein, we report an atom-efficient, rapid, green, and sustainable approach to synthesize isoquinolines and isoquinolinones using a homogeneous recyclable ruthenium catalyst in PEG Media assisted by microwave energy. Dibenzoylhydrazine was used for C–H/N–N activation reactions for the first time in combination with ketazine as oxidizing directing groups for annulation reactions with internal alkynes. The developed protocol is environmentally benign due to significantly shortened times with an easy extraction method, higher atom economy, external oxidant and silver or antimony salt free conditions, applicability to a gram scale synthesis, use of biodegradable solvent and wide substrate scope with higher product yields. Moreover, it is worth noting that the established methodology allowed reuse of the catalytic system for up to five successive runs with minimal loss in activity.

Synthesis and in vitro urease inhibitory activity of benzohydrazide derivatives, in silico and kinetic studies

Benzohydrazide derivatives 1–43 were synthesized via “one-pot” reaction and structural characterization of these synthetic derivatives was carried out by different spectroscopic techniques such as 1H NMR and EI-MS. The synthetic molecules were evaluated for their in vitro urease inhibitory activity. All synthetic derivatives showed good inhibitory activities in the range of (IC50 = 0.87 ± 0.31–19.0 ± 0.25 μM) as compared to the standard thiourea (IC50 = 21.25 ± 0.15 μM), except seven compounds 17, 18, 23, 24, 29, 30, and 41 which were found to be inactive. The most active compound of the series was compound 36 (IC50 = 0.87 ± 0.31 μM) having two chloro groups at meta positions of ring A and methoxy group at para position of ring B. The structure–activity relationship (SAR) of the active compounds was established on the basis of different substituents and their positions in the molecules. Kinetic studies of the active compounds revealed that compounds can inhibit enzyme via competitive and noncompetitive modes. In silico study was also performed to understand the binding interactions of the molecules (ligand) with the active site of enzyme.

Oxidation of Hydrazine Derivatives with Arylsulfonyl Peroxides

A new method for the generation of the azo function is reported.A series of hydrazine derivatives, which included alkyl- and arylhydrazines, monoacylhydrazides, and diacylhydrazides, was oxidized with m-(trifluoromethyl)benzenesulfonyl peroxide.Smooth conversion to the diimide was observed.The diimides then yielded products typical of normal degradation pathways.