2639-17-0

Usage

Physical appearance

white to light brown crystalline powder

Solubility

insoluble in water, soluble in organic solvents

Uses

Synthesis of organic electronic materials
Intermediate in the production of pharmaceuticals and fine chemicals
Potential fluorescent material
Potential pesticide
Potential anti-cancer agent

Biological activities

Ability to inhibit cell proliferation
Ability to induce apoptosis in cancer cells
Further research needed to fully understand biological activities and potential applications

Upstream product

• 38192-14-2 3-chloro-N'-(3′-chlorobenzoyl)benzohydrazide 
• 618-46-2 m-Chlorobenzoyl chloride 
• 304456-31-3 C₁₄H₁₀Cl₂N₂O 
• 587-04-2 m-Chlorobenzaldehyde 
• 1673-47-8 3-chlorobenzhydrazide 
• 535-80-8 3-chlorobenzoate 

Downstream Products

• 787-84-8 N'-benzoylbenzohydrazide 
• 75029-44-6 1,3-dimethyl-5-benzoylpyrimidine-2,4(1H,3H)-dione 
• 75029-39-9 5-(3-Chlorbenzoyl)-1,3-dimethyluracil-(3-chlorbenzoyl)hydrazon 
• 65-85-0 benzoic acid 

Relevant academic research and scientific papers

Electrochemical oxidation of aldehyde-N-arylhydrazones into symmetrical-2,5-disubstituted-1,3,4-oxadiazoles

A convenient, efficient and one-pot synthesis of chemically and pharmaceutically interesting symmetrical-2,5-disubstituted-1,3,4-oxadiazoles is reported. The protocol involves anodic oxidation of aldehyde-N-arylhydrazones in anhyd. MeCN-LiClO4. Constant potential electrolysis carried out in an undivided cell and platinum electrodes leads to the formation of the corresponding oxadiazoles under ambient condition and the mechanism was deduced from voltammetry studies. The reaction proceeded smoothly with high atom economy. Springer Science+Business Media Dordrecht 2013.

A new efficient one-pot synthesis of 2,5-diaryl-1,3,4-oxadiazoles

Symmetrically substituted 2,5-diaryl-1,3,4-oxadiazoles have been prepared in 81-92% yields by a new direct one-pot synthesis from arenecarboxylic acids, hydrazine dihydrochloride, anhydrous phosphoric acid and sodium borohydride in the absence of a solvent at 170-180°C for 5-6h.

An efficient one pot synthesis of 1,3,4-oxadiazoles

Various 1,3,4-oxadiazoles have been synthesized in excellent yields by BF3·Et2O promoted cyclodehydration of 1,2-diacyl and diaroyl hydrazines prepared in situ from corresponding acid chlorides and hydrazine.