38201-64-8

Usage

InChI:InChI=1/C8H8N2OS2/c1-3-4(2)13-7-5(3)6(11)9-8(12)10-7/h1-2H3,(H2,9,10,11,12)

Upstream product

• 132424-47-6 5,6-Dimethyl-4-m-tolylamino-1H-thieno[2,3-d]pyrimidine-2-thione 
• 132424-46-5 5,6-Dimethyl-4-p-tolylamino-1H-thieno[2,3-d]pyrimidine-2-thione 
• 132424-45-4 5,6-Dimethyl-4-phenylamino-1H-thieno[2,3-d]pyrimidine-2-thione 
• 132424-48-7 4-(4-Chloro-phenylamino)-5,6-dimethyl-1H-thieno[2,3-d]pyrimidine-2-thione 
• 132424-49-8 4-(4-Methoxy-phenylamino)-5,6-dimethyl-1H-thieno[2,3-d]pyrimidine-2-thione 
• 1147550-11-5 ammonium thiocyanate 
• 4815-24-1 2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester 
• 4651-94-9 2-amino-4,5-dimethylthiophene-3-carbonitrile 
• 132167-26-1 4-Imino-5,6-dimethyl-3-m-tolyl-3,4-dihydro-1H-thieno[2,3-d]pyrimidine-2-thione 
• 132167-18-1 1-(3-Cyano-4,5-dimethyl-thiophen-2-yl)-3-(4-methoxy-phenyl)-thiourea 
• 819819-17-5 2-[(ethylcarbamothioyl)amino]-4,5-dimethylthiophene-3-carboxamide 
• 51486-04-5 2-amino-4,5-dimethylthiophene-3-carboxamide 
• 542-85-8 Ethyl isothiocyanate 
• 622-59-3 1-isothiocyanato-4-methylbenzene 

Downstream Products

• 276255-32-4 2,3-dihydro-6,7-dimethyl-2-(phenylmethylene)-5H-thiazolo[3,2-a]thieno[2,3-d]pyrimidine-3,5-dione 
• 42518-50-3 2-(ethylthio)-5,6-dimethyl-3H,4H-thieno[2,3-d]pyrimidin-4-one 
• 146381-74-0 (6,7-dimethyl-1-oxo-1,2-dihydrothieno[2,3-d]pyrimidin-3-ylsulfanyl)acetic acid ethyl ester 
• 53074-16-1 5,6-dimethyl-2-methylthio-3,4-dihydrothieno[2,3-d]pyrimidin-4-one 
• 54968-60-4 (6,7-dimethyl-1-oxo-1,2-dihydrothieno[2,3-d]pyrimidin-3-ylsulfanyl)acetic acid 
• 52881-19-3 5,6-dimethyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-3H-thieno[2,3-d]pyrimidin-4-one 
• 1084955-60-1 C₂₄H₁₆N₄O₃S 
• 1084955-56-5 C₁₈H₁₆N₄O₃S 
• 1084955-59-8 C₂₂H₁₆N₄O₂S 
• 1084955-58-7 C₂₂H₁₇N₅O₂S 
• 1084955-57-6 C₁₇H₁₄N₄O₂S 
• 54968-62-6 2,3-dimethyl-8-phenyl-4H-thiazolo <3,2-a> thieno <3.2-e> pyrimidine-4-one 
• 52881-22-8 6,7-dimethyl-3-phenyl-5H-thiazolo <3,2-a> thieno <2,3-d> pyrimidine-5-one 

Relevant academic research and scientific papers

Oxidative cyclocondensation of cyclic thio-and selenoureas. 5. 2-Thioxothieno-and 2-thioxopyrido[2,3-d]pyrimidin-4-ones

A study was carried out on the oxidative cyclocondensation of 2-thioxothieno-and 2-thioxopyrido[2,3-d]pyrimidin-4-ones. The thiophene ring with excess π-electron density facilitates the reaction, while the pyridine ring with diminished π-electron density hinders it. 2-Thioxothieno-[2,3-d] pyridimin-4-ones were converted into previously unreported 7H,13H-[1,2,4] thiadiazolo-[3,2-b:5,4-b′]bis(thieno[2,3-d]pyridimine-7,13-diones).

Synthesis, characterization and biological studies of some novel thieno[2,3-d]pyrimidines

Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2-aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolothienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using

Investigation into the reaction of 2-amino- 4,5-dimethylthiophene-3- carboxamide with iso(and Isothio)cyanates under microwave irradiation

The reaction of 2-amino-4,5-dimethyl-thiophene-3-carboxamide with iso(and isothio) cyanates for the synthesis ofthieno[2,3-d]pyrimidines has been investigated. The reactions under microwave irradiation in the presence of N,N-dimethyl acetamide as solvent

MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH

The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

The Dimroth rearrangement: Synthesis and interconversion of isomeric triazolothienopyrimidines

Triazolo-thieno[3,2-e]pyrimidines obtained by cyclisation of 4-hydrazino-2-(methylthio)thieno[2,3-d]pyrimidine with formic acid, acetic acid, cyanogen bromide and carbon disulfide, and by oxidation of the derived aldehyde hydrazones, are found to be the triazolo[4,3-c] isomers. These [4,3-c] compounds resist isomerisation in acid, but they undergo Dimroth rearrangement to the [1,5-c] isomers under basic conditions. The crystal structure of one such rearranged product, 5-methoxy-8,9,10,11-tetrahydro[1]benzothieno[3,2-e][1,2,4] triazolo[1,5-c]pyrimidine (13b) was confirmed by X-ray analysis.

Crystal and molecular structure of 2H- and 2-(p-tolylamino)-5,6-dimethylthieno[2,3-d]pyrimidin-4-ones

The crystal and molecular structure of 2H- and 2-(p-tolylamino)-5,6-dimethylthieno[2,3-d]pyrimidin-4-ones was investigated by X-ray diffraction. In crystals, the tautorneric form with a localized N(1)=C(2) bond is realized. A comparative analysis of the two structures using the literature data is given to examine the conjugation effect on the geometrical parameters of a pseudoaromatic pyrimidine system.