51486-04-5Relevant articles and documents
Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase
Massari, Serena,Bertagnin, Chiara,Pismataro, Maria Chiara,Donnadio, Anna,Nannetti, Giulio,Felicetti, Tommaso,Di Bona, Stefano,Nizi, Maria Giulia,Tensi, Leonardo,Manfroni, Giuseppe,Loza, Maria Isabel,Sabatini, Stefano,Cecchetti, Violetta,Brea, Jose,Goracci, Laura,Loregian, Arianna,Tabarrini, Oriana
, (2020/10/27)
Influenza viruses (Flu) are responsible for seasonal epidemics causing high rates of morbidity, which can dramatically increase during severe pandemic outbreaks. Antiviral drugs are an indispensable weapon to treat infected people and reduce the impact on
Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H
Masaoka, Takashi,Chung, Suhman,Caboni, Pierluigi,Rausch, Jason W.,Wilson, Jennifer A.,Taskent-Sezgin, Humeyra,Beutler, John A.,Tocco, Graziella,Le Grice, Stuart F. J.
supporting information, p. 5436 - 5445 (2013/07/26)
The thienopyrimidinone 5,6-dimethyl-2-(4-nitrophenyl)thieno[2,3-d] pyrimidin-4(3H)-one (DNTP) occupies the interface between the p66 ribonuclease H (RNase H) domain and p51 thumb of human immunodeficiency virus reverse transcriptase (HIV RT), thereby indu
A novel series of positive modulators of the AMPA receptor: Discovery and structure based hit-to-lead studies
Jamieson, Craig,Basten, Stephanie,Campbell, Robert A.,Cumming, Iain A.,Gillen, Kevin J.,Gillespie, Jonathan,Kazemier, Bert,Kiczun, Michael,Lamont, Yvonne,Lyons, Amanda J.,MacLean, John K.F.,Moir, Elizabeth M.,Morrow, John A.,Papakosta, Marianthi,Rankovic, Zoran,Smith, Lynn
scheme or table, p. 5753 - 5756 (2010/12/18)
Starting from an HTS derived hit 1, application of biostructural data facilitated rapid optimization to lead 22, a novel AMPA receptor modulator. This is the first demonstration of how structure based drug design can be exploited in an optimization program for a glutamate receptor.
Iodine catalysed synthesis and antibacterial evaluation of thieno-[2,3-d]pyrimidine derivatives
Bakavoli, Mehdi,Bagherzadeh, Ghodsieh,Vaseghifar, Maryam,Shiri, Ali,Pordeli, Parvaneh
experimental part, p. 653 - 655 (2010/03/24)
A new route via iodine catalysed heterocyclisation of 2-amino-4,5- dimethylthiophene-3-carboxamide with aromatic aldehydes affording a series of thieno[2,3-d]pyrimidine derivatives in a single step have been developed. Some of these compounds exhibited an
PYRAZOLEALKANAMIDE SUBSTITUTED THIOPHENES AS AMPA POTENTIATORS
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Page/Page column 46, (2008/06/13)
The present invention relates to a heterocyclic derivative according to Formula (I) wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceuti