38205-66-2

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(4-thiazolyl)(9CI) is used as a neuroprotective and anti-inflammatory agent for the treatment of various neurological disorders and inflammatory conditions. Its ability to modulate immune responses and protect neurons makes it a promising candidate for therapeutic applications.
Used in Chemical Research and Drug Discovery:
Ethanone, 1-(4-thiazolyl)(9CI) serves as a building block in the synthesis of various organic compounds. Its unique chemical properties and reactivity make it an essential tool for chemists in the development of new drugs and advanced materials.

InChI:InChI=1/C5H5NOS/c1-4(7)5-2-8-3-6-5/h2-3H,1H3

Upstream product

• 68158-16-7 4-acetylthialoze oxime 
• 1452-15-9 thiazole-4-carbonitrile 
• 917-64-6 methyl magnesium iodide 
• 936371-70-9 N-methoxy-N-methylthiazole-4-carboxamide 
• 75-16-1 methylmagnesium bromide 
• 3973-08-8 Thiazole-4-carboxylic acid 
• 917-54-4 methyllithium 
• 769933-82-6 1-[2-(trimethyl-silanyl)-thiazol-4-yl]-ethanone 
• 90817-58-6 1-Thiazol-4-yl-ethanone oxime; hydrobromide 

Downstream Products

• 69567-27-7 6-chloro-4-phenyl-2-thiazol-4-yl-quinoline 
• 69808-92-0 1-thiazol-4-yl-ethanone phenylhydrazone 
• 38923-13-6 2-bromo-1-(thiazol-4-yl)ethanone 
• 26489-43-0 2-bromo-1-(thiazol-4-yl)ethanone hydrobromide 
• 38923-02-3 6-bromo-2-thiazol-4-yl-imidazo[1,2-a]pyridine 
• 129593-87-9 6-(4-{N'-[1-Thiazol-4-yl-eth-(E)-ylidene]-hydrazino}-phenyl)-4,5-dihydro-2H-pyridazin-3-one 

Relevant academic research and scientific papers

CHIRAL INDOLE COMPOUNDS AND THEIR USE

The present disclosure relates to indole compounds of Structural Formula 2 and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer. Formula (II)

Cyanocuprates convert carboxylic acids directly into ketones

Carboxylic acids were converted directly in 56-99% yields into methyl, n-butyl, and isopropyl ketones using excess cyanocuprates R2CuLi 3 LiCN. A substrate with a stereocenter α to the carboxylic acid was converted into ketones with very little loss of enantiomeric purity. A variety of functional groups were tolerated including aryl bromides. This direct transformation of a carboxylic acid into ketone with minimal tertiary alcohol formation is proposed to involve a relatively stable copper ketal tetrahedral intermediate.

SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS

The invention pertains to heteroaromatic compounds of the formula I, as defined herein, that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.

Kinetics of the Enolisation Reactions of 2-Acetylpyrrole and of 2-, 4- and 5-Acetylthiazoles

Kinetic results are reported on the rates of enolisation of title compounds in water, in acetate buffers, in dilute hydrochloric acid, in dilute sodium hydroxide solutions and in the presence of several metal-ion salts, as measured by their rates of halogenation at 25 deg C.The results have been compared with those previously obtained from the corresponding reactions of acetophenone and a number of acetylheterocycles.It is shown that a suitable metal cation (e.g., Cu2+) can be hundreds of times more effective than the proton in catalysing the enolisation process of an acetylheterocyclic compound.This can be due either to the 'soft' character of the acetyl group, as, for example, that of 2-acetylpyrrole, or to coordination of both the carbonyl oxygen and the heteroatom by the metal cation in the transition state of the reaction, as for 2- and 4-acetylthiazoles.