38205-66-2

Basic information

• Product Name: Ethanone, 1-(4-thiazolyl)- (9CI)
• Synonyms: Ethanone, 1-(4-thiazolyl)- (9CI);1-(4-Thiazolyl)-ethanone;4-Acetylthiazole;Methyl 4-thiazolyl ketone;4-Acetylthiozole;Ethanone,1-(4-thiazolyl)-;1-(1,3-thiazol-4-yl)ethan-1-one;1-(4-Thiazolyl)
• CAS NO: 38205-66-2
• Molecular Formula: C₅H₅NOS
• Molecular Weight: 127.1643
• Product Categories: ACETYLGROUP
• Mol File: 38205-66-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 56℃
• Boiling Point: 220℃
• Flash Point: 87℃
• Appearance: /
• Density: 1.226
• Vapor Pressure: 0.113mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.19±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-(4-thiazolyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-thiazolyl)- (9CI)(38205-66-2)
• EPA Substance Registry System: Ethanone, 1-(4-thiazolyl)- (9CI)(38205-66-2)

Safety Data

• Hazardous Substances Data: 38205-66-2(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(4-thiazolyl)- (9CI) is a chemical compound with the molecular formula C5H5NOS. It is a thiazole derivative that is commonly used in the pharmaceutical and chemical industries. Ethanone, 1-(4-thiazolyl)- (9CI) is known for its ability to act as a neuroprotective and anti-inflammatory agent. It has also been studied for its potential applications in the treatment of various neurological disorders and inflammatory conditions. Additionally, it has been used as a building block in the synthesis of various organic compounds, making it a valuable tool in chemical research and drug discovery. Overall, Ethanone, 1-(4-thiazolyl)- (9CI) is a versatile chemical with significant potential for pharmaceutical and industrial applications.

InChI:InChI=1/C5H5NOS/c1-4(7)5-2-8-3-6-5/h2-3H,1H3

Upstream product

• 1452-15-9 thiazole-4-carbonitrile 
• 917-64-6 methyl magnesium iodide 
• 3973-08-8 Thiazole-4-carboxylic acid 
• 917-54-4 methyllithium 
• 936371-70-9 N-methoxy-N-methylthiazole-4-carboxamide 
• 75-16-1 methylmagnesium bromide 
• 769933-82-6 1-[2-(trimethyl-silanyl)-thiazol-4-yl]-ethanone 
• 90817-58-6 1-Thiazol-4-yl-ethanone oxime; hydrobromide 
• 68158-16-7 4-acetylthialoze oxime 

Downstream Products

• 69567-27-7 6-chloro-4-phenyl-2-thiazol-4-yl-quinoline 
• 69808-92-0 1-thiazol-4-yl-ethanone phenylhydrazone 
• 38923-13-6 2-bromo-1-(thiazol-4-yl)ethanone 
• 26489-43-0 2-bromo-1-(thiazol-4-yl)ethanone hydrobromide 
• 38923-02-3 6-bromo-2-thiazol-4-yl-imidazo[1,2-a]pyridine 
• 129593-87-9 6-(4-{N'-[1-Thiazol-4-yl-eth-(E)-ylidene]-hydrazino}-phenyl)-4,5-dihydro-2H-pyridazin-3-one 

Relevant articles and documents

CHIRAL INDOLE COMPOUNDS AND THEIR USE

The present disclosure relates to indole compounds of Structural Formula 2 and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer. Formula (II)

SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS

The invention pertains to heteroaromatic compounds of the formula I, as defined herein, that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.

Kinetics of the Enolisation Reactions of 2-Acetylpyrrole and of 2-, 4- and 5-Acetylthiazoles

Kinetic results are reported on the rates of enolisation of title compounds in water, in acetate buffers, in dilute hydrochloric acid, in dilute sodium hydroxide solutions and in the presence of several metal-ion salts, as measured by their rates of halogenation at 25 deg C.The results have been compared with those previously obtained from the corresponding reactions of acetophenone and a number of acetylheterocycles.It is shown that a suitable metal cation (e.g., Cu2+) can be hundreds of times more effective than the proton in catalysing the enolisation process of an acetylheterocyclic compound.This can be due either to the 'soft' character of the acetyl group, as, for example, that of 2-acetylpyrrole, or to coordination of both the carbonyl oxygen and the heteroatom by the metal cation in the transition state of the reaction, as for 2- and 4-acetylthiazoles.