382147-23-1Relevant academic research and scientific papers
Synthetic and biological studies on coumarin hydrazone derivatives
El-Sayed,Abd Allah
, p. 75 - 86 (2001)
The reaction of both of coumarin and 6-nitrocoumarin hydrazones (1,4) with alkyl(aryl)isothiocyanate afforded the corresponding 3-N[alkyl(aryl)thioamido] coumarins 3a-d or benzopyrano[2,3-c]pyrazole-3-thione derivatives 6a-d, respectively. Compounds (3a-d) were used as key intermediates for the preparation of benzopyrano-pyridine derivatives (7a-d & 10a) or benzopyranoazepine derivatives 8a,c & 12a-d through the reaction with different acyl halides or ethoxymethylenemalononitriles and subsequent cyclization. Biological activity of some new compounds against Gram +ve and Gram -ve were given.
