Synthetic and biological studies on coumarin hydrazone derivatives

Article abstract of DOI:10.1080/10426500108040586

The reaction of both of coumarin and 6-nitrocoumarin hydrazones (1,4) with alkyl(aryl)isothiocyanate afforded the corresponding 3-N[alkyl(aryl)thioamido] coumarins 3_a-d or benzopyrano[2,3-c]pyrazole-3-thione derivatives 6a-d, respectively. Compounds (3_a-d) were used as key intermediates for the preparation of benzopyrano-pyridine derivatives (7_a-d & 10_a) or benzopyranoazepine derivatives 8_a,c & 12_a-d through the reaction with different acyl halides or ethoxymethylenemalononitriles and subsequent cyclization. Biological activity of some new compounds against Gram +ve and Gram -ve were given.

Full text of DOI:10.1080/10426500108040586

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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SYNTHETIC AND BIOLOGICAL
STUDIES ON COUMARIN
HYDRAZONE DERIVATIVES
A. M. El-sayed a & O. A. Abd Allah a
a Chemistry Department, Faculty of Science, South
Valley University, Sohag, Egypt
Version of record first published: 27 Oct 2006.
To cite this article: A. M. El-sayed & O. A. Abd Allah (2001): SYNTHETIC AND
BIOLOGICAL STUDIES ON COUMARIN HYDRAZONE DERIVATIVES, Phosphorus, Sulfur, and
Silicon and the Related Elements, 170:1, 75-86
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