382162-12-1

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 90331-86-5 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]isoindoline-1,3-dione 
• 112-60-7 Tetraethylene glycol 
• 77544-60-6 p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester 
• 136918-14-4 phthalimide 
• 37860-51-8 tetraethylene glycol di(p-toluenesulfonate) 

Downstream Products

• 382162-17-6 dimethyl 2,3-bis{[N-[11-[2-allyloxy-3-(4,5-dihydro-1,3-dioxol-2-yl)phenoxy]-3,6,9-trioxaundecyl]carbamoyl]methoxy}terephthalate 
• 382162-19-8 2,3-bis[[N-[11-(2-allyloxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene 
• 382162-22-3 2,3-bis[[N-[11-(2-hydroxy-3-formylphenoxy)-3,6,9-trioxaundecyl]carbamoyl]methoxy]-1,4-bis(hydroxymethyl)benzene 
• 382162-14-3 N-[11-(2-allyloxy-3-(4,5-dihydro-1,3-dioxol-2-yl)phenoxy)-3,6,9-trioxaundecyl]phthalimide 
• 382162-15-4 11-[2-allyloxy-3-(4,5-dihydro-1,3-dioxol-2-yl)phenoxy]-3,6,9-trioxaundecylamine 
• 382162-13-2 N-[11-(2-allyloxy-3-formylphenoxy)-3,6,9-trioxaundecyl]phthalimide 

Relevant academic research and scientific papers

Discriminating detection between Mg2+ and Ca2+ by fluorescent signal from anthracene aromatic amide moiety

(Chemical Equation Presented) Novel fluorescent reagents 1 and 2 were synthesized. In the absence of metal ions, the fluorescence emissions of these compounds were quite weak, but their intensities were much greater in the presence of alkaline earth metal

Design and synthesis of protoporphyrin IX/vitamin B12 molecular hybrids via CuAAC reaction

The design and synthesis of new molecular hybrids composed of protoporphyrin IX (PPIX) and vitamin B12 via copper catalyzed alkyne azide cycloaddition reaction is described. New, clickable aminoazide and aminoalkyne linkers were prepared and subsequently attached to PPIX (via vinyl group) and to vitamin B12 giving desired building blocks. Preliminary results showed that respective water soluble hybrids were formed under CuAAC reaction. Gratifyingly, Cu incorporation into the PPIX core was avoided, which was important for further biological studies. Copyright

HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME

The present subject matter relates to a compound represented by the general formula (I) or (I') or a pharmacologically acceptable salt thereof; pharmaceutical compositions containing at least one of these compounds; methods of making at least one of these compounds; methods of using at least one of these compounds for treating and/or preventing various cancers and/or proliferation disorders; methods of using at least one of these compounds for monitoring the effectiveness of an anticancer therapy against various cancers. In one embodiment, the subject matter relates to compounds that bind with a level of specificity to heat shock protein 70 (Hsp70). In another embodiment, the subject matter relates to compounds that bind with a level of specificity to inhibit both heat shock protein 70 (Hsp70) and heat shock cognate protein 70 (Hsc70).

Cooperative and ion-pair recognition by heteroditopic calix[4]diquinone receptors

A new family of heteroditopic calix[4]diquinone receptors capable of the cooperative recognition of ion-pair species through a contact binding mechanism has been developed. The receptors bind contact ion pairs cooperatively, with an unprecedented AND recognition phenomenon being observed to operate in certain cases, in which receptors display no affinity for either of the individual "free" cation or anion, but bind the cation and anion ion-pair strongly. X-ray crystallographic, solution-state, and computational methods rationalize the observed recognition behavior of the receptors. It is shown that the contact ion-pair interaction occurs through a π-stacking-mediated folding of the receptors such that the anion and cation binding sites are arranged in close proximity, while in the solid state an unusual ion-mediated receptor dimerization is observed. Molecular dynamics simulations are further used to explain the observed trends in the association constants of different ion-pair species and the mechanism of interaction.

Novel chemosensor for alkaline earth metal ion based on 9-anthryl aromatic amide using a naphthalene as a TICT control site and intramolecular energy transfer donor

Novel fluorescent chemosensors 1 and 2 with two different fluorophores (naphthalene and anthracene) at the both ends of polyether was synthesized. These compounds based on 9-anthryl aromatic amide adopted a naphthalene as a TICT controller and an intramol

Electroorganic reactions. Part 55. Quinodimethane chemistry. Part 3. Transition metal complexes as inter- and intra-molecular redox catalysts for the electrosynthesis of poly(p-xylylene) (PPX) polymers and oligomers

The role of metal complexes as redox mediators in the electrosynthesis of poly(p-xylylenes) (PPXs) has been explored, with a view to designing metal-containing precursors that can act both as mediators and starting materials for metal-containing polymers. A number of transition metal complexes [Cr(III), Ni(II) and Co(II)] are efficient redox catalysts for production of quinodimethanes, and hence PPXs. Following encouraging results from experiments using mediators based on anthranilic acid and salicylaldehyde ligands a macrocyclic compound was designed, and successfully prepared by a convergent route that incorporated both a 1,4-bis(chloromethylarene) function as a precursor to a quinodimethane and a Ni(II) salen unit as an intramolecular redox catalyst. The macrocycle was successfully reduced cathodically to yield a PPX polymer with bound Ni(II). Evidence is presented for the operation of intramolecular redox catalysis (homomediation).