38220-75-6

Basic information

• Product Name: 1-(5-BROMO-1-BENZOFURAN-2-YL)ETHANONE
• Synonyms: 2-ACETYL-5-BROMOBENZO[B]FURAN;2-ACETYL-5-BROMO BENZOFURAN;1-(5-BROMO-1-BENZOFURAN-2-YL)ETHANONE;2-Acetyl-5-bromobenzobüfuran;Ethanone, 1-(5-broMo-2-benzofuranyl)-;1-(5-Bromo-benzofuran-2-yl)ethanone
• CAS NO: 38220-75-6
• Molecular Formula: C₁₀H₇BrO₂
• Molecular Weight: 239.07
• Mol File: 38220-75-6.mol
• Article Data: 25

Chemical Properties

• Melting Point: 111 °C
• Boiling Point: 314.4 °C at 760 mmHg
• Flash Point: 144 °C
• Appearance: /
• Density: 1.551 g/cm³
• Vapor Pressure: 0.000467mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 1-(5-BROMO-1-BENZOFURAN-2-YL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-BROMO-1-BENZOFURAN-2-YL)ETHANONE(38220-75-6)
• EPA Substance Registry System: 1-(5-BROMO-1-BENZOFURAN-2-YL)ETHANONE(38220-75-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 38220-75-6(Hazardous Substances Data)

Usage

General Description

1-(5-Bromo-1-benzofuran-2-yl)ethanone is a chemical compound with the molecular formula C10H7BrO2. It is a brominated benzofuran derivative that is commonly used in organic synthesis and pharmaceutical research. 1-(5-Bromo-1-benzofuran-2-yl)ethanone has a benzofuran ring structure with a bromine atom attached to the 5-position, and a ketone functional group attached to the 1-position. It is often used as a building block in the synthesis of biologically active molecules and as a reagent in various chemical reactions. Its unique structure and reactivity make it a valuable tool in the development of new drugs and materials.

InChI:InChI=1/C10H7BrO2/c1-6(12)10-5-7-4-8(11)2-3-9(7)13-10/h2-5H,1H3

Upstream product

• 78-95-5 chloroacetone 
• 67-64-1 acetone 
• 1761-61-1 5-bromosalicyclaldehyde 
• 635-93-8 5-chlorosalicyclaldehyde 
• 598-31-2 1-bromoacetone 
• 638-07-3 ethyl (2-chloroaceto)acetate 

Downstream Products

• 10242-11-2 5-bromobenzo[b]furan-2-carboxylic acid 
• 84102-83-0 5-Cyan-1-benzofuran-2-carbonylchlorid 
• 84102-75-0 5-cyanobenzo[b]furan-2-carboxylic acid 
• 84102-97-6 5-Cyan-N-(4-cyanphenyl)-1-benzofuran-2-carboxamid 
• 84102-98-7 5-Amidino-N-(4-amidinophenyl)-1-benzofuran-2-carboxamid-dihydrochlorid 
• 84102-99-8 4',5-Bis(2-imidazolin-2-yl)-1-benzofuran-2-carboxanilid-dihydrochlorid 

Relevant articles and documents

5-Bromobenzofuran analog of chloramphenicol (1)

-

PROTEIN KINASE C AGONISTS

The present disclosure relates generally to certain diacylglycerol lactone compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions dis

Synthesis and bioactivity of novel C2-glycosyl benzofuranylthiazoles derivatives as acetylcholinesterase inhibitors

A new series of C2-glycosyl benzofuranylthiazole derivatives was synthesised by the further cyclization of glycosyl thiourea and 2-(bromoacetyl)-benzofuran via Hantzsch’s method. The corresponding 2-(bromoacetyl)-benzofuran derivatives were obtained by the reaction from various salicylaldehydes, and the glycosyl thiourea was prepared through a series of steps from D-Glucosamine. The acetylcholinesterase-inhibitory activities of the products were tested by Ellman’s method. The most active compounds were subsequently evaluated for the 50% inhibitory concentration values. N-(1,3,4,6-tetra-O-benzyl-2-deoxy-β-D-glucopyranosyl)-4-(5-methoxy-benzofuran-2-yl)-1,3-thiazole-2-amine possessed the best acetylcholinesterase-inhibition activity with a 50% inhibitory concentration of 2.03 ± 0.26 μM.