38226-86-7

Basic information

• Product Name: Anhydroicaritin
• Synonyms: Anhydroicaritin;9,10-Dihydro-3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one;4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one,9,10-dihydro-3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-
• CAS NO: 38226-86-7
• Molecular Formula: C₂₁H₂₀O₆
• Molecular Weight: 368.3799
• Mol File: 38226-86-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 222-223 °C
• Boiling Point: 582°C at 760 mmHg
• Flash Point: 206.7°C
• Appearance: /
• Density: 1.349
• Vapor Pressure: 3.82E-14mmHg at 25°C
• Refractive Index: 1.656
• Storage Temp.: 2-8°C(protect from light)
• PKA: 6.56±0.60(Predicted)
• CAS DataBase Reference: Anhydroicaritin(CAS DataBase Reference)
• NIST Chemistry Reference: Anhydroicaritin(38226-86-7)
• EPA Substance Registry System: Anhydroicaritin(38226-86-7)

Safety Data

• Hazardous Substances Data: 38226-86-7(Hazardous Substances Data)

Usage

Uses

β-Anhydroicaritin is an Icartin (I163680) derivative displaying anti-inflammatory activity and inhibition of human phosphodiesterase-5.

InChI:InChI=1/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3

Upstream product

• 128988-53-4 C₃₉H₅₀O₂₀ 
• 64-18-6 formic acid 
• 55929-05-0 3,4'-di-O-methyl-8-(3-methyl-2-butenyl)kaempferol 
• 118525-40-9 icaritin 
• 83171-42-0 4,6-dimethoxy-2-(4'-methoxybenzoyloxy)acetophenone 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 28610-35-7 3,5-diacetoxy-2-(4-acetoxy-phenyl)-8,8-dimethyl-9,10-dihydro-8H-pyrano[2,3-f]chromen-4-one 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1186604-08-9 5-hydroxy-3-sulfamide-4'-methoxy-6'',6''-dimethyl-4'',5''-dihydropyrano[2'',3'':7,8]-flavone 
• 1186604-09-0 3,5-dihydroxy-4'-methoxy-3'-sulfonic acid-6'',6''-dimethyl-4'',5''-dihydropyrano[2'',3'':7,8]-flavone 
• 1186604-07-8 5-hydroxy-3-methanesulfonyl-4'-methoxy-6'',6''-dimethyl-4'',5''-dihydropyrano[2'',3'':7,8]-flavone 
• 55395-02-3 3,5,4'-trimethoxy-6'',6''-dimethyldihydropyrano<2'',3'':7,8>flavone 
• 55395-01-2 5-hydroxy-3-methoxy-2-(4-methoxyphenyl)-7,8-(2,2-dimethyl-2H-pyran)-4H-chromen-4-one 

Relevant articles and documents

5-substituted icaritin derivative and anti-tumor application thereof

The invention provides a 5-substituted icaritin derivative as shown in a structural formula 4, and a preparation method and anti-tumor application thereof. Activity tests prove that the 5-substitutedicaritin derivative as shown in 4 is designed and synthesized in the invention, is a suitable anti-tumor candidate drug, and especially can be used as an anti-liver cancer candidate drug, an anti-colon cancer candidate drug, an anti-lung cancer candidate drug and an anti-colon cancer candidate drug. Besides, the preparation method of the 5-substituted icaritin derivative is high in synthetic routeyield and easy to operate and implement.

Flavone derivative and preparation method and medical application of flavone derivative

The invention relates to a flavone derivative and a preparation method and medical application of the flavone derivative. The flavone derivative is prepared through a mode that anhydroicaritin is taken as a mother nucleus, and group addition and reduction are conducted. It is proved through a pharmacological experiment that the flavone derivative has the pharmacological effect of activating endogenous stem cells in the body, achieves the effects of repairing injury-type pathological changes of blood vessel cells, nerve cells, endothelial cells and the matrix and recovering functions, can be used for preparing medicines for repairing the tissue-injury pathological changes and has a good prospect in preparing medicines for conducting rehabilitation treatment on erectile dysfunction pathological changes.

Method for preparing dewatered icaritin through total-synthesis

The invention provides a method for preparing dewatered icaritin through total-synthesis. The method includes the steps of connecting an isopentene group to 8th-position carbon through ortho-positionrearrangement with methoxybenzoyl chloride, isoprenyl bromide and the like as the raw materials by means of trihydroxyacetophenone, and conducting the forming series reaction of a flavone framework toobtain the dewatered icaritin. The defects that in a traditional method of introducing an isopentene group, the yield is low, catalysts are expensive and lots of byproducts are produced are overcome,and the method is low in cost, simple in operation, good in yield and suitable for industrial production.