38231-91-3

Upstream product

• 131156-33-7 ethyl 2-methyltetradecanoate 
• 4292-19-7 1-Iodododecane 
• 609-08-5 Diethyl methylmalonate 
• 6683-71-2 2-methylmyristic acid 
• 143-15-7 1-dodecylbromide 
• 67-64-1 acetone 
• 1120-36-1 1-tetradecene 
• 201230-82-2 carbon monoxide 
• 112-54-9 Dodecanal 
• 66344-23-8 ethyl 3-methyltetradecanoate 

Relevant academic research and scientific papers

PYRROLE DERIVATIVES AS ACC INHIBITORS

Novel pyrrole derivatives of Formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Acetyl-CoA carboxylase (ACC).

From alkenes to alcohols by cobalt-catalyzed hydroformylation-reduction

The cobalt-catalyzed hydroformylation of alkenes in the presence of a range of novel cyclic phosphine ligands was investigated. The effect of various parameters such as solvents, additives, cobalt/phosphine ratio, CO/H2 (1:2), and nature of the alkenes was examined. The results revealed that both terminal and internal alkenes are hydroformylated in high yields to give mainly linear products at moderate temperature and syn gas pressure. The linearity ranges from 43 to 85%, with Lim-10 giving the highest proportion of linear product.

Lack of the neighboring group rate effect in solvolytic reactions that proceed via participation

In order to investigate the influence of solvent polarity on the rate effect of double bonds in reactions that proceed via an extended π-participation mechanism, the solvolysis rates (kU) of the benzyl chloride derivative 1 and tertiary chlorid

Enantioselective Transesterifications of 2-Methyl-1-alcohols Catalysed by Lipases from Pseudomonas

Racemic β-methyl-2-thiophenepropanol was resolved (E = 200) via transesterification catalysed by lipase from Pseudomonas fluorescens using an excess of vinyl acetate in chloroform at an initial water activity: aw = 0.32.When trying to resolve rac-2-methyl-1-alkanols more modest E-values were obtained (E = 10) and were of the same order of magnitude irrespective of substrate chainlength, water activity, immobilization, acyl donor or other Pseudomonas derived lipases.However, the reaction rates are affected by variations of these parameters.Both the rates and E-values were influenced by the nature of the solvent.