38240-12-9

Upstream product

• 75-44-5 phosgene 
• 589-91-3 p-methylcyclohexanol 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 37653-95-5 4-(4-Methyl-cyclohexyloxycarbonylamino)-benzoic acid 
• 37653-70-6 (4-Chlorocarbonyl-phenyl)-carbamic acid 4-methyl-cyclohexyl ester 

Relevant academic research and scientific papers

Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as new antitubercular agents with potent in vitro and in vivo efficacy

A series of 3-amino-5-benzylphenol derivatives were designed and synthesized. Among them, (3-benzyl-5-hydroxyphenyl)carbamates were found to exert good inhibitory activity against M. tuberculosis H37Ra, H37Rv and clinically isolated multidrug-resistant M. tuberculosis strains (MIC = 0.625-6.25 μg/mL). The privileged compounds 3i and 3l showed moderate cytotoxicity against cell line A549. Compound 3l also exhibited potent in vivo inhibitory activity on a mouse infection model via the oral administration. The results demonstrated 3-hydroxyphenylcarbamates as a class of new antitubercular agents with good potential.