38258-52-5

Upstream product

• 18594-05-3 4-cyclohexylacetophenone 
• 827-52-1 1-phenyl-1-cyclohexane 
• 110-82-7 cyclohexane 
• 2142-63-4 1-(3-Bromophenyl)ethanone 

Downstream Products

• 38258-63-8 3-(3-Brom-4-cyclohexyl-benzoyl)-acrylsaeure 
• 59721-37-8 (e)-4-(3-bromo-4-cyclohexyl-phenyl)-3-pentene-2-one 
• 59721-51-6 4-(3-bromo-4-cyclohexyl-phenyl)-2-pentanol 

Relevant academic research and scientific papers

Nickel-Catalyzed, para-Selective, Radical-Based Alkylation of Aromatic Ketones

A direct, para-selective, radical-based alkylation of aromatic ketones with alkanes has been developed using a nickel catalyst with oxamide as the ligand. Acetophenones bearing electron-withdrawing substituents were functionalized directly with simple alkanes with high para-selectivity while acetophenones with electron-donating groups were mainly para-functionalized. A mechanistic study indicated that C-H bond activation of the aromatic ring may be the rate-determining step of the reaction.

Preparation method of siponimod intermediate

The invention relates to a preparation method of a siponimod intermediate, belonging to the field of medicinal chemistry. The preparation method comprises the following steps: with cyclohexylbenzene as a starting material, carrying out reactions such as Friedel-Crafts acylation, bromination, oxidation, esterification, trifluoromethylation and hydrolysis to obtain 4-cyclohexyl-3-trifluoromethyl benzoic acid. Such a technical scheme provided by the invention is simple and convenient to operate, easy to implement, mild in reaction conditions, high in yield, high in purity, low in cost and suitable for industrial production.

Preparation method of 4-cycloalkylacetophenone derivatives

The invention discloses a preparation method of 4-cycloalkylacetophenone derivatives, and belongs to the technical field of organic compounds. A 2-substituted acetophenone derivative or a 3-substituted acetophenone derivative is used as an initiator, so raw materials are easy to obtain and have many kinds; and the 4-substituted cycloalkyl acetophenone derivatives obtained by using the method are various, can be directly used, and can also be used in other further reactions. The preparation method has the advantages of simplicity in reaction operation and post-treatment, high yield, and no generation of a large amount of metal salts, is a green method with high atom economy, and is suitable for large-scale production.