38260-54-7 Usage
Description
Etrimfos is a colorless liquid, mp ?3.35 ?C, vp 6.5 mPa
(20 ?C). Solubility in water is 40 mg/L (23–24 ?C). It is
miscible with most organic solvents. Log Kow > 3.3. Neat
etrimfos is unstable and degrades ca. 40% in 28 d at
50 ?C, but the dilute solutions in nonpolar solvents and its
formulations are stable (about 5% loss in 1 y at ca. 20 ?C).
It is hydrolyzed in aqueous media; DT50 (25 ?C) at pH 3, 6,
and 9 are 0.4, 16, and 14 d, respectively.
Uses
Different sources of media describe the Uses of 38260-54-7 differently. You can refer to the following data:
1. Satisfar is a pesticide sprayed on plants and vegetables as insecticide to fend off pests.
2. Agricultural insecticide.
3. Etrimfos is used to control chewing insects in top fruit, vines,
olives and a number of other crops. It is also used to control stem borers in
rice and insect and acarid pests of stored products.
Hazard
Toxic.
Metabolic pathway
Etrimfos is principally degraded in soil and plants via dearylation of
etrimfos itself or by hydrolysis of etrimfos oxon to the pyrimidinol
(6-ethoxy-4-hydroxy-2-ethylpyrimidine), further metabolism of which
involves de-ethylation to a dihydroxypyrimidine (2-ethyl-4,6-dihydroxypyrimidine).
In mammals both hydrolysis and demethylation to desmethyl
etrimfos are involved in detoxification. Additionally, the ethyl and
ethoxy groups of the pyrimidinol hydrolysis product may be hydroxylated
and conjugated. Etrimfos oxon is metabolically highly unstable and
is often not detected.
Degradation
Etrimfos is unstable when pure but dilute solutions in non-polar solvents
and formulations are stable. Half-lives in water at pH 3,6 and 9 were 0.4,
16 and 14 days, respectively. Etrimfos is stable to light (PM).
Toxicity evaluation
The acute oral LD50 for rats is 1,600–1,800 mg/kg.
Inhalation LC50 (1 h) for rats is >200 mg/L air. NOEL
(2 yr) for rats is 6 mg/kg diet (0.3 mg/kg/d). ADI is
3 μg/kg b.w. The principal degradation pathway in
mammals, plants, and soils is pyrimidinyl ester bond
cleavage: the major metabolites are 6-ethoxy-4-hydroxy-
2-ethylpyrimidine and its further transformed products.
Degradation in mammals involves demethylation to
desmethyl etrimfos. The DT50 in soils at pH 6.8 was
3–10 d.
Check Digit Verification of cas no
The CAS Registry Mumber 38260-54-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,2,6 and 0 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 38260-54:
(7*3)+(6*8)+(5*2)+(4*6)+(3*0)+(2*5)+(1*4)=117
117 % 10 = 7
So 38260-54-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H17N2O4PS/c1-5-8-11-9(15-6-2)7-10(12-8)16-17(18,13-3)14-4/h7H,5-6H2,1-4H3
38260-54-7Relevant articles and documents
Investigation on the acylation of heterocyclic alcoholate anions with O,O-dialkyl phosphorochloridothioate in water solvent
Ge, Xin,Qian, Chao,Chen, Xinzhi
supporting information, p. 739 - 744 (2013/07/25)
The acylation of some heterocyclic alcoholate anions with O,O-dialkyl phosphorochloridothioate has been investigated. Higher yields and fewer byproducts were achieved in water at 50 °C by employing an effective phase-transfer catalyst (PTC) (benzyl triethylammonium chloride [BTEAC]), acylation catalyst (AC) (4-dimethylaminopyridine), and surfactant (sodium dodecyl sulfate), under weakly basic (pH 9.5～10) conditions. This reaction can also be applied to synthesize other insecticides with excellent yields.
