38266-46-5Relevant academic research and scientific papers
Highly efficient Michael addition reaction of amines catalyzed by silica-supported aluminum chloride
Saidi, Mohammad R.,Pourshojaei, Yaghoub,Aryanasab, Fezzeh
experimental part, p. 1109 - 1119 (2009/09/08)
Aliphatic and aromatic amines undergo smooth nucleophilic addition to α,β-unsaturated compounds in the presence of a catalytic amount of silica-supported aluminum chloride at 60°C and under solvent-free conditions to produce the corresponding β-amino compounds in excellent yields. This method is simple and convenient and works efficiently under mild conditions. This catalyst can used again without losing its activity three times. Copyright Taylor & Francis Group, LLC.
Synthesis of Benzoquinolinoisoxazoles and Benzoquinolinopyrazoles
Subramanian, Lakshmi M.,Misra, G. S.
, p. 440 - 444 (2007/10/02)
1-Oxo-2,3-dihydro-1H-benzo- and 1-acetyl-4-oxo-2,3-dihydro-4H-benzo-quinolines (1 and 2) have been synthesised starting from 2-naphthylamine and 1-acetamidonaphthalene, respectively.Reaction of diethyl oxalate or formylation of these compounds followed by treatment with reagents like hydroxylamine hydrochloride, hydrazine hydrate, phenylhydrazine, semicarbazide hydrochloride, thiosemicarbazide hydrochloride lead to isoxazole and pyrazole fused benzo- and benzo-quinolines (4,8 and 5,9 respectively).
