38275-48-8

Basic information

• Product Name: 5-BROMO-2-METHANESULFONYL-PYRIMIDINE
• Synonyms: 5-BROMO-2-METHANESULFONYL-PYRIMIDINE;Pyrimidine, 5-bromo-2-(methylsulfonyl)-;5-Bromopyrimidin-2-yl methyl sulphone;5-Bromopyrimidin-2-yl methyl sulphone, 5-Bromo-2-(methylsulphonyl)-1,3-diazine;NSC 262216
• CAS NO: 38275-48-8
• Molecular Formula: C₅H₅BrN₂O₂S
• Molecular Weight: 237.0744
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 38275-48-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 130-133°C
• Boiling Point: 393.7 °C at 760 mmHg
• Flash Point: 191.9 °C
• Appearance: /
• Density: 1.771 g/cm³
• Vapor Pressure: 4.73E-06mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -4.78±0.22(Predicted)
• CAS DataBase Reference: 5-BROMO-2-METHANESULFONYL-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-METHANESULFONYL-PYRIMIDINE(38275-48-8)
• EPA Substance Registry System: 5-BROMO-2-METHANESULFONYL-PYRIMIDINE(38275-48-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 38275-48-8(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-methanesulfonyl-pyrimidine is a chemical compound used in organic synthesis. It is a pyrimidine derivative that contains a bromine atom and a methanesulfonyl group. 5-BROMO-2-METHANESULFONYL-PYRIMIDINE is commonly used as a reagent in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and intermediates. It is also used in the production of specialty chemicals and advanced materials. 5-Bromo-2-methanesulfonyl-pyrimidine is a versatile building block in organic chemistry, and it has a wide range of applications in the development of new drugs, crop protection products, and other fine chemicals.

InChI:InChI=1/C5H5BrN2O2S/c1-11(9,10)5-7-2-4(6)3-8-5/h2-3H,1H3

Upstream product

• 79685-17-9 5-bromo-2-(methylsulfinyl)pyrimidine 
• 14001-67-3 5-bromo-2-methylthiopyrimidine 

Downstream Products

• 1093847-78-9 (RS)-N-(ethoxycarbonyl)-S-(3-{[5-bromo-pyrimindin-2-yl]amino}phenyl)-S-methylsulfoximide 
• 1295501-96-0 2-methanesulfonyl-5-phenylethynylpyrimidine 
• 433683-47-7 5-bromo-2-(2,2,2-trifluoroethoxy)pyrimidine 

Relevant articles and documents

Oxidative kinetic resolution of heterocyclic sulfoxides with a porphyrin-inspired manganese complex by hydrogen peroxide

We have successfully reported here the low loading porphyrin-inspired high-valent manganese (IV)-oxo complex was applied in oxidative kinetic resolution (OKR) of racemic heterocyclic sulfoxides using the environmentally benign hydrogen peroxide for the first time. This approach allows for rapid OKR (0.5 h) of a variety of racemic sulfoxides (including pyridine, pyrimidine, pyrazine, thiazole, benzothiazole, thiophene) in excellent enantioselectivity (up to > 99% ee), simultaneously generating the corresponding sulfones in high yield (up to 80%). The catalytic system also showed an unexceptionable chemoselectivity for the sulfoxide substrates with hydroxyl groups in which only the sulfoxide group was oxidized. The practical utility of the method has been demonstrated in the OKR of gram-scale sulfoxides.

ALKYNYLPYRIMIDINES AS TIE2 KINASE INHIBITORS

The invention relates to alkynylpyrimidines according to the general formula (I) in which A, R1, R2, R3, R4, R5, and R6 are as defined in the claims, to pharmaceutical compositions comprising said alkynylpyrimidines, to methods of preparing said alkynylpyrimidines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 and VEGFR2 signalling.