38275-48-8

Usage

Uses

Used in Pharmaceutical Industry:
5-BROMO-2-METHANESULFONYL-PYRIMIDINE is used as a reagent for the synthesis of active ingredients and intermediates. It plays a crucial role in the development of new drugs, contributing to the advancement of pharmaceutical compounds with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical sector, 5-BROMO-2-METHANESULFONYL-PYRIMIDINE is utilized as a reagent in the synthesis of crop protection products. Its application aids in the creation of effective agents that protect crops from pests and diseases, thereby ensuring agricultural productivity.
Used in Specialty Chemicals Production:
5-BROMO-2-METHANESULFONYL-PYRIMIDINE is used as a component in the production of specialty chemicals. Its unique properties allow it to be incorporated into various chemical formulations that serve specific industrial needs.
Used in Advanced Materials Development:
5-BROMO-2-METHANESULFONYL-PYRIMIDINE is also used in the development of advanced materials. Its presence in these materials can enhance their properties, making them suitable for high-performance applications in various industries.

InChI:InChI=1/C5H5BrN2O2S/c1-11(9,10)5-7-2-4(6)3-8-5/h2-3H,1H3

Upstream product

• 14001-67-3 5-bromo-2-methylthiopyrimidine 
• 79685-17-9 5-bromo-2-(methylsulfinyl)pyrimidine 

Downstream Products

• 433683-47-7 5-bromo-2-(2,2,2-trifluoroethoxy)pyrimidine 
• 1093847-78-9 (RS)-N-(ethoxycarbonyl)-S-(3-{[5-bromo-pyrimindin-2-yl]amino}phenyl)-S-methylsulfoximide 
• 1295501-96-0 2-methanesulfonyl-5-phenylethynylpyrimidine 

Relevant academic research and scientific papers

METALLOENZYME INHIBITOR COMPOUNDS

Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.

Oxidative kinetic resolution of heterocyclic sulfoxides with a porphyrin-inspired manganese complex by hydrogen peroxide

We have successfully reported here the low loading porphyrin-inspired high-valent manganese (IV)-oxo complex was applied in oxidative kinetic resolution (OKR) of racemic heterocyclic sulfoxides using the environmentally benign hydrogen peroxide for the first time. This approach allows for rapid OKR (0.5 h) of a variety of racemic sulfoxides (including pyridine, pyrimidine, pyrazine, thiazole, benzothiazole, thiophene) in excellent enantioselectivity (up to > 99% ee), simultaneously generating the corresponding sulfones in high yield (up to 80%). The catalytic system also showed an unexceptionable chemoselectivity for the sulfoxide substrates with hydroxyl groups in which only the sulfoxide group was oxidized. The practical utility of the method has been demonstrated in the OKR of gram-scale sulfoxides.

ALKYNYLPYRIMIDINES AS TIE2 KINASE INHIBITORS

The invention relates to alkynylpyrimidines according to the general formula (I) in which A, R1, R2, R3, R4, R5, and R6 are as defined in the claims, to pharmaceutical compositions comprising said alkynylpyrimidines, to methods of preparing said alkynylpyrimidines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 and VEGFR2 signalling.