433683-47-7

Basic information

• Product Name: 5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE
• Synonyms: 5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE
• CAS NO: 433683-47-7
• Molecular Formula: C₆H₄BrF₃N₂O
• Molecular Weight: 257.0079696
• Mol File: 433683-47-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 249.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.725±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: -1.12±0.22(Predicted)
• CAS DataBase Reference: 5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE(433683-47-7)
• EPA Substance Registry System: 5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE(433683-47-7)

Safety Data

• Hazardous Substances Data: 433683-47-7(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-(2,2,2-trifluoro-ethoxy)-pyrimidine is a chemical compound with the molecular formula C6H3BrF3N2O. It is a pyrimidine derivative containing a bromine atom and a trifluoroethoxy group. 5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE is commonly used as a building block in organic synthesis and pharmaceutical research. It is a versatile intermediate that can be used in the synthesis of various biologically active compounds. Its unique structure and properties make it a valuable tool for drug discovery and development. Furthermore, its potential applications in agrochemicals and material science make it an important compound in chemical research and development.

Upstream product

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Downstream Products

• 433683-46-6 5-{4-[5-(2,6-difluorophenyl)-3,4-dihydro-2H-pyrrol-2-yl]phenyl}-2-(2,2,2-trifluorethoxy)pyrimidine 
• 1351234-12-2 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyrimidine 
• 1401163-85-6 [2-(2,2,2-trifluoroethoxy)pyrimidin-5-yl]boronic acid 

Relevant articles and documents

SUBSTITUTED PYRIDAZINONE FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES

Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-α.

HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE

The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I): wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

PYRIDAZINONE COMPOUNDS AND USES THEREOF

Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-α.