38280-24-9

Upstream product

• 574-19-6 1-(2-hydroxy-1-naphthyl)ethan-1-one 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 166761-75-7 3-(2-hydroxy-1-naphthyl)-5-(4-chloro-phenyl)-2-isoxazoline 
• 152598-55-5 Co(OC₁₀H₆C₃H₄N₂C₆H₄Cl)2(C₅H₅N)2 
• 152579-17-4 Ni(OC₁₀H₆C₃H₄N₂C₆H₄Cl)2(C₅H₅N)2 
• 1192824-32-0 RuCl(CO)(P(C₆H₅)3)2OC₁₀H₆COCHCHC₆H₄Cl 
• 152579-20-9 Co(OC₁₀H₆C₃H₄N₂C₆H₄Cl)2(H₂O)2 

Relevant academic research and scientific papers

Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein

Breast cancer resistance protein (BCRP/ABCG2) belongs to the ATP binding cassette family of transport proteins. BCRP has been found to confer multidrug resistance in cancer cells. A strategy to overcome resistance due to BCRP overexpression is the investigation of potent and specific BCRP inhibitors. The aim of the current study was to investigate different multi-substituted chalcones for their BCRP inhibition. We synthesized chalcones and benzochalcones with different substituents (viz. OH, OCH3, Cl) on ring A and B of the chalcone structure. All synthesized compounds were tested by Hoechst 33342 accumulation assay to determine inhibitory activity in MCF-7 MX and MDCK cells expressing BCRP. The compounds were also screened for their P-glycoprotein (P-gp) and Multidrug resistance-associated protein 1 (MRP1) inhibitory activity in the calcein AM accumulation assay and were found to be selective towards inhibition of BCRP. Substituents at position 2′ and 4′ on chalcone ring A were found to be essential for activity; additionally there was a great influence of substituents on ring B. Presence of 3,4-dimethoxy substitution on ring B was found to be optimal, while presence of 2- and 4-chloro substitution also showed a positive effect on BCRP inhibition.

Ruthenium(II) chalconate complexes: Synthesis, characterization, catalytic, and biological studies

A series of new hexa-coordinated ruthenium(II) carbonyl complexes of the type [RuCl(CO)(EPh3)(B)(L)] (E = P or As; B = PPh3, AsPh3 or Py; L = 2′-hydroxychalcones) have been prepared by reacting [RuHCl(CO)(EPh3)2(B)] (E = P or As; B = PPh3, AsPh3 or Py) with 2′-hydroxychalcones in benzene under reflux. The new complexes have been characterized by analytical and spectral (IR, electronic, 1H, 31P and 13C NMR) data. Based on the above data, an octahedral structure has been assigned for all the complexes. The new complexes exhibit catalytic activity for the oxidation of primary and secondary alcohols into their corresponding aldehydes and ketones in the presence of N-methylmorpholine-N-oxide (NMO) as co-oxidant and also found efficient catalyst in the transfer hydrogenation of ketones. The antifungal properties of the complexes have also been examined and compared with standard Bavistin.

Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2″-hydroxy naphthalen-1″-yl)-1,5-diphenyl-2-pyrazolines

Five new 1,3,5-triphenyl-2-pyrazolines were synthesised by reacting 1,3-diphenyl-2-propene-1-one with phenyl hydrazine hydrochloride and another five new 3-(2″-hydroxy naphthalen-1″-yl)-1,5-diphenyl-2-pyrazolines were synthesised by reacting 1-(2′-hydroxy

Condensed 1,8-Naphthyridines. Part-VI. Synthesis of 8-Aryl-8H-naphthopyranonaphthyridines

The condensation of 2-aminonicotinaldehyde (1) with substituted-2-hydroxy-1-naphthyl styryl ketones (2) in the presence of glacial acetic acid containing a catalytic amount of concentrated sulphuric acid affords the corresponding 8-aryl-8H-naphtho1',2':5